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- W2015075737 abstract "A novel approach of producing positron emission tomography (PET) imaging agents through the formation of bioconjugates based on a pegylation−fluorination strategy resulting in fluoro-pegylated (FPEG) molecules is reported. This approach offers a simple and easy method by which to incorporate 18F in the target molecule without an appreciable increase in the lipophilicity. After 18F labeling, this convenient approach leads to PET imaging probes binding to Aβ aggregates in the brain (an important factor associated with Alzheimer's disease) using the known core structures, such as [2-(4-dimethylaminophenyl)-vinyl]-benzoxazol (3‘) or 2-phenylbenzothiazole (4). This approach appears to be effective in some core structures, but it cannot be uniformly applied to all structures." @default.
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- W2015075737 date "2006-12-23" @default.
- W2015075737 modified "2023-09-26" @default.
- W2015075737 title "Fluoro-pegylated (FPEG) Imaging Agents Targeting Aβ Aggregates" @default.
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- W2015075737 doi "https://doi.org/10.1021/bc060239q" @default.
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