FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015079454> ?p ?o ?g. }

• W2015079454 endingPage "37" @default.
• W2015079454 startingPage "31" @default.
• W2015079454 abstract "We previously reported that the time frame and the extent of the changes in the peripheral neurogenic inflammatory response in the skin area, innervated by an injured nerve, coincide with those of pain behaviours. We raised the possibility that common factors might operate to modulate neuropathic pain and peripheral neurogenic processes in rats with chronic constriction nerve injury (CCI). In the present study we examined the role of free radicals in modulating the neurogenic vascular response and thermal hyperalgesia in rats with CCI of the sciatic nerve. Free radicals, via an interaction with nitric oxide (NO) to form peroxynitrite, have previously been implicated in the maintenance of thermal hyperalgesia in CCI rats. In this study, we induced CCI of the sciatic nerve and the activity of xanthine oxidase (XO), which catalyzes the formation of superoxide anions, was measured in the injured nerve. In addition, we examined the effect of antioxidants on thermal hyperalgesia and on the neurogenic vascular response to substance P (SP) perfused over the base of a blister induced on the hind footpad skin which is innervated by the injured sciatic nerve. Compared with the sham operated group, CCI rats had a significantly higher XO activity in the injured sciatic nerve and significantly reduced thermal threshold and peripheral neurogenic vascular response to SP. Treatment with antioxidants, superoxide dismutase (SOD) or tirilazad significantly improved the neurogenic vascular response while tirilazad treatment significantly alleviated thermal hyperalgesia. The results therefore, suggest that free radicals are elevated in CCI animals and that they contribute to the maintenance of thermal hyperalgesia and the reduction in peripheral microvascular blood flow in the area innervated by the injured nerve. We raise the possibility that common mechanisms may govern the changes in neuropathic pain and in the peripheral neurogenic vascular responses in tissues innervated by the injured nerve." @default.
• W2015079454 created "2016-06-24" @default.
• W2015079454 creator A5006168466 @default.
• W2015079454 creator A5015120603 @default.
• W2015079454 creator A5046282420 @default.
• W2015079454 date "1999-01-01" @default.
• W2015079454 modified "2023-10-18" @default.
• W2015079454 title "Free radicals contribute to the reduction in peripheral vascular responses and the maintenance of thermal hyperalgesia in rats with chronic constriction injury" @default.
• W2015079454 cites W140339473 @default.
• W2015079454 cites W1593761027 @default.
• W2015079454 cites W195217094 @default.
• W2015079454 cites W1965866432 @default.
• W2015079454 cites W1969668074 @default.
• W2015079454 cites W1976798000 @default.
• W2015079454 cites W1979882313 @default.
• W2015079454 cites W1981313663 @default.
• W2015079454 cites W1993697980 @default.
• W2015079454 cites W1998024253 @default.
• W2015079454 cites W2001341182 @default.
• W2015079454 cites W2003213627 @default.
• W2015079454 cites W2013040468 @default.
• W2015079454 cites W2013221973 @default.
• W2015079454 cites W2016018088 @default.
• W2015079454 cites W2016597337 @default.
• W2015079454 cites W2018841629 @default.
• W2015079454 cites W2020033019 @default.
• W2015079454 cites W2022843959 @default.
• W2015079454 cites W2032203225 @default.
• W2015079454 cites W2034225514 @default.
• W2015079454 cites W2039156019 @default.
• W2015079454 cites W2039414634 @default.
• W2015079454 cites W2041286410 @default.
• W2015079454 cites W2058020736 @default.
• W2015079454 cites W2058137293 @default.
• W2015079454 cites W2067392851 @default.
• W2015079454 cites W2067924690 @default.
• W2015079454 cites W2068436964 @default.
• W2015079454 cites W2071553665 @default.
• W2015079454 cites W2072698244 @default.
• W2015079454 cites W2076637488 @default.
• W2015079454 cites W2081477394 @default.
• W2015079454 cites W2082107259 @default.
• W2015079454 cites W2084159987 @default.
• W2015079454 cites W2093342117 @default.
• W2015079454 cites W2093518775 @default.
• W2015079454 cites W2093933800 @default.
• W2015079454 cites W2097744068 @default.
• W2015079454 cites W2098798964 @default.
• W2015079454 cites W2137838742 @default.
• W2015079454 cites W2172077475 @default.
• W2015079454 cites W2415897859 @default.
• W2015079454 cites W2461732215 @default.
• W2015079454 doi "https://doi.org/10.1016/s0304-3959(98)00143-2" @default.
• W2015079454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9928773" @default.
• W2015079454 hasPublicationYear "1999" @default.
• W2015079454 type Work @default.
• W2015079454 sameAs 2015079454 @default.
• W2015079454 citedByCount "131" @default.
• W2015079454 countsByYear W20150794542012 @default.
• W2015079454 countsByYear W20150794542013 @default.
• W2015079454 countsByYear W20150794542014 @default.
• W2015079454 countsByYear W20150794542015 @default.
• W2015079454 countsByYear W20150794542016 @default.
• W2015079454 countsByYear W20150794542017 @default.
• W2015079454 countsByYear W20150794542018 @default.
• W2015079454 countsByYear W20150794542019 @default.
• W2015079454 countsByYear W20150794542020 @default.
• W2015079454 countsByYear W20150794542021 @default.
• W2015079454 countsByYear W20150794542022 @default.
• W2015079454 countsByYear W20150794542023 @default.
• W2015079454 crossrefType "journal-article" @default.
• W2015079454 hasAuthorship W2015079454A5006168466 @default.
• W2015079454 hasAuthorship W2015079454A5015120603 @default.
• W2015079454 hasAuthorship W2015079454A5046282420 @default.
• W2015079454 hasConcept C126322002 @default.
• W2015079454 hasConcept C15490471 @default.
• W2015079454 hasConcept C170493617 @default.
• W2015079454 hasConcept C181199279 @default.
• W2015079454 hasConcept C185592680 @default.
• W2015079454 hasConcept C2775991916 @default.
• W2015079454 hasConcept C2776880756 @default.
• W2015079454 hasConcept C2777107010 @default.
• W2015079454 hasConcept C2778102346 @default.
• W2015079454 hasConcept C2778784160 @default.
• W2015079454 hasConcept C2779245659 @default.
• W2015079454 hasConcept C2780795997 @default.
• W2015079454 hasConcept C2781149210 @default.
• W2015079454 hasConcept C42219234 @default.
• W2015079454 hasConcept C519581460 @default.
• W2015079454 hasConcept C55493867 @default.
• W2015079454 hasConcept C71924100 @default.
• W2015079454 hasConcept C98274493 @default.
• W2015079454 hasConceptScore W2015079454C126322002 @default.
• W2015079454 hasConceptScore W2015079454C15490471 @default.
• W2015079454 hasConceptScore W2015079454C170493617 @default.
• W2015079454 hasConceptScore W2015079454C181199279 @default.
• W2015079454 hasConceptScore W2015079454C185592680 @default.
• W2015079454 hasConceptScore W2015079454C2775991916 @default.

• next