Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015080479> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2015080479 endingPage "342" @default.
- W2015080479 startingPage "335" @default.
- W2015080479 abstract "OBJECTIVE: Cerebral cavernous malformations (CCMs) are associated with hemorrhagic proliferation of endothelial-lined vascular caverns, resulting in hemorrhagic stroke, epilepsy, and other neurological manifestations. We hypothesize that structural protein expression and endothelial cell proliferation markers within CCM lesions are different in the setting of various clinical manifestations. METHODS: The percentage of immunohistochemically stained caverns positive for collagen IV, fibronectin, laminin, α-smooth muscle actin, myosin, and smoothelin and the percentage of dividing endothelial cells within caverns were determined in 36 excised CCM surgical specimens. These were compared in CCMs with different multiplicity, location, and size in patients of different age, sex, seizure status, and hemorrhage status. RESULTS: Comparisons of seven lesion features and clinical manifestations with the fraction of caverns containing the structural proteins studied and endothelial cell proliferation demonstrated no significant differences. A possible exception was the difference (P < 0.05) in the fraction (mean ± standard deviation) of positively stained caverns for collagen IV between adult (0.63 ± 0.39) and pediatric patients (0.87 ± 0.21) as well as fewer caverns with laminin expression in older patients. These trends did not sustain significance with Bonferroni’s correction for multiple comparisons. CONCLUSION: The fraction of caverns containing the particular structural proteins studied and endothelial cell proliferation within caverns are not correlated with particular lesion features and clinical manifestations that were investigated in CCMs. The possible fewer fractions of caverns containing collagen IV and laminin in adult lesions compared with pediatric lesions may have implications for lesion regression and quiescence with age." @default.
- W2015080479 created "2016-06-24" @default.
- W2015080479 creator A5006782404 @default.
- W2015080479 creator A5049334372 @default.
- W2015080479 creator A5050082012 @default.
- W2015080479 creator A5077178401 @default.
- W2015080479 creator A5090555830 @default.
- W2015080479 date "2005-02-01" @default.
- W2015080479 modified "2023-10-13" @default.
- W2015080479 title "Variations in Structural Protein Expression and Endothelial Cell Proliferation in Relation to Clinical Manifestations of Cerebral Cavernous Malformations" @default.
- W2015080479 cites W1969511928 @default.
- W2015080479 cites W1978851591 @default.
- W2015080479 cites W1986359374 @default.
- W2015080479 cites W1986538711 @default.
- W2015080479 cites W1989910396 @default.
- W2015080479 cites W1996565603 @default.
- W2015080479 cites W2016167439 @default.
- W2015080479 cites W2025334571 @default.
- W2015080479 cites W2045523777 @default.
- W2015080479 cites W2063163828 @default.
- W2015080479 cites W2066308459 @default.
- W2015080479 cites W2070205590 @default.
- W2015080479 cites W2076654705 @default.
- W2015080479 cites W2083384380 @default.
- W2015080479 cites W2084178947 @default.
- W2015080479 cites W2087218466 @default.
- W2015080479 cites W2096332334 @default.
- W2015080479 cites W2098986683 @default.
- W2015080479 cites W2110537012 @default.
- W2015080479 cites W2112958616 @default.
- W2015080479 cites W2143461429 @default.
- W2015080479 cites W2148194026 @default.
- W2015080479 cites W2150713212 @default.
- W2015080479 cites W2154184667 @default.
- W2015080479 cites W2157638088 @default.
- W2015080479 cites W2170202796 @default.
- W2015080479 doi "https://doi.org/10.1227/01.neu.0000148903.11469.e9" @default.
- W2015080479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15670382" @default.
- W2015080479 hasPublicationYear "2005" @default.
- W2015080479 type Work @default.
- W2015080479 sameAs 2015080479 @default.
- W2015080479 citedByCount "12" @default.
- W2015080479 countsByYear W20150804792015 @default.
- W2015080479 countsByYear W20150804792016 @default.
- W2015080479 countsByYear W20150804792020 @default.
- W2015080479 countsByYear W20150804792022 @default.
- W2015080479 crossrefType "journal-article" @default.
- W2015080479 hasAuthorship W2015080479A5006782404 @default.
- W2015080479 hasAuthorship W2015080479A5049334372 @default.
- W2015080479 hasAuthorship W2015080479A5050082012 @default.
- W2015080479 hasAuthorship W2015080479A5077178401 @default.
- W2015080479 hasAuthorship W2015080479A5090555830 @default.
- W2015080479 hasConcept C123012128 @default.
- W2015080479 hasConcept C142724271 @default.
- W2015080479 hasConcept C1491633281 @default.
- W2015080479 hasConcept C202751555 @default.
- W2015080479 hasConcept C2779756704 @default.
- W2015080479 hasConcept C2779814568 @default.
- W2015080479 hasConcept C2781156865 @default.
- W2015080479 hasConcept C54355233 @default.
- W2015080479 hasConcept C55493867 @default.
- W2015080479 hasConcept C71924100 @default.
- W2015080479 hasConcept C86492073 @default.
- W2015080479 hasConcept C86803240 @default.
- W2015080479 hasConceptScore W2015080479C123012128 @default.
- W2015080479 hasConceptScore W2015080479C142724271 @default.
- W2015080479 hasConceptScore W2015080479C1491633281 @default.
- W2015080479 hasConceptScore W2015080479C202751555 @default.
- W2015080479 hasConceptScore W2015080479C2779756704 @default.
- W2015080479 hasConceptScore W2015080479C2779814568 @default.
- W2015080479 hasConceptScore W2015080479C2781156865 @default.
- W2015080479 hasConceptScore W2015080479C54355233 @default.
- W2015080479 hasConceptScore W2015080479C55493867 @default.
- W2015080479 hasConceptScore W2015080479C71924100 @default.
- W2015080479 hasConceptScore W2015080479C86492073 @default.
- W2015080479 hasConceptScore W2015080479C86803240 @default.
- W2015080479 hasIssue "2" @default.
- W2015080479 hasLocation W20150804791 @default.
- W2015080479 hasLocation W20150804792 @default.
- W2015080479 hasOpenAccess W2015080479 @default.
- W2015080479 hasPrimaryLocation W20150804791 @default.
- W2015080479 hasRelatedWork W1541725716 @default.
- W2015080479 hasRelatedWork W179758183 @default.
- W2015080479 hasRelatedWork W1979554718 @default.
- W2015080479 hasRelatedWork W2011759501 @default.
- W2015080479 hasRelatedWork W2029789401 @default.
- W2015080479 hasRelatedWork W2108864068 @default.
- W2015080479 hasRelatedWork W2203225155 @default.
- W2015080479 hasRelatedWork W2352011868 @default.
- W2015080479 hasRelatedWork W2379354152 @default.
- W2015080479 hasRelatedWork W2410922236 @default.
- W2015080479 hasVolume "56" @default.
- W2015080479 isParatext "false" @default.
- W2015080479 isRetracted "false" @default.
- W2015080479 magId "2015080479" @default.
- W2015080479 workType "article" @default.