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• W2015083350 abstract "Objective The authors review their recent experience with resected pancreatic ductal adenocarcinoma. Summary Background Data Ductal adenocarcinoma of the pancreas has traditionally had a 5-year survival rate less than 10% after curative resection. Recently, several groups have reported markedly improved 5-year survival rates (approaching 25%) for patients undergoing curative resection. Methods Institutional experience with 186 consecutive patients (1981–1991) with pathologic diagnoses of ductal adenocarcinoma undergoing pancreatic resection was reviewed. Histologic specimens of all 3-year survivors (n = 31) were re-reviewed by two pathologists, one internal and one external; nonductal pancreatic cancers then were excluded. Results After histologic re-review, 12 patients did not have ductal adenocarcinoma, leaving a total of 174 patients for analysis (102 men, 72 women; mean age 63 years, range 34–82 years). Mean followup was 22 months (range 4–109). Classical pancreaticoduodenectomy was performed in 71%, pylorus-preserving resection in 9%, and total pancreatectomy in 20%. Hospital mortality was 3%. Twenty-eight patients (16%) had macroscopically incomplete resections; 98 (56%) had lymph node metastases within the resected specimens, and 21 patients (12%) had extensive perineural invasion. Overall actuarial 5-year survival was 6.8%. Five-year survival was greater for nodenegative versus node-positive patients (14% vs. 1%, p< 0.001), and for smaller (<2 cm) versus larger tumors (20% vs. 1%, p< 0.001). The 5-year survival for the subset of patients with negative nodes and no perineural or duodenal invasion (69 patients) was 23% (p< 0.001). Mean survival of the 12 excluded patients was 53 ± 7 months compared with 17.5 ± 1 months in the 174 patients with ductal pancreatic cancer. Conclusions Five-year survival for patients undergoing pancreatic resection for lesions deemed to be clinically “curable” intraoperatively and histologically reviewed/confirmed to be ductal adenocarcinoma of the pancreas is approximately 7%. Survival is greater (23%) in the subset of patients with negative" @default.
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• W2015083350 date "1995-01-01" @default.
• W2015083350 modified "2023-09-25" @default.
• W2015083350 title "Long-Term Survival After Resection for Ductal Adenocarcinoma of the Pancreas Is It Really Improving?" @default.
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• W2015083350 doi "https://doi.org/10.1097/00000658-199501000-00007" @default.
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