FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015083544> ?p ?o ?g. }

• W2015083544 endingPage "195" @default.
• W2015083544 startingPage "187" @default.
• W2015083544 abstract "Background The role of the epidermis in the immune response is well known. While multiple cytokines are implicated in keratinocyte-mediated infection clearance and wound healing, little is known about the involvement of keratinocytes in promoting resolution of inflammation. Aim To assess effects of histamine stimulation on keratinocyte function. Methods We performed a combined microarray/Gene Ontology analysis of histamine-stimulated keratinocytes. Functional changes were tested by apoptosis assessment and scratch assays. Histamine receptor involvement was also assessed by blocking wound closure with specific antagonists. Results Histamine treatment had extensive effects on keratinocytes, including effects on proinflammatory responses and cellular functions promoting wound healing. At the functional level, there was reduced apoptosis and enhancement of wound healing in vitro. At the receptor level, we identified involvement of all keratinocyte-expressed histamine receptors (HRHs), with HRH1 blockage resulting in the most prominent effect. Conclusions Histamine activates wound healing and infection clearance-related functions of keratinocytes. While enhancement of histamine-mediated wound healing is mediated predominantly via the HRH1 receptor, other keratinocyte-expressed receptors are also involved. These effects could promote resolution of skin inflammation caused by infection or superficial injury." @default.
• W2015083544 created "2016-06-24" @default.
• W2015083544 creator A5007252427 @default.
• W2015083544 creator A5013661223 @default.
• W2015083544 creator A5030623879 @default.
• W2015083544 creator A5050511886 @default.
• W2015083544 creator A5060928869 @default.
• W2015083544 date "2014-01-23" @default.
• W2015083544 modified "2023-09-27" @default.
• W2015083544 title "Histamine enhances keratinocyte-mediated resolution of inflammation by promoting wound healing and response to infection" @default.
• W2015083544 cites W108899424 @default.
• W2015083544 cites W1487706295 @default.
• W2015083544 cites W1505157620 @default.
• W2015083544 cites W1899881065 @default.
• W2015083544 cites W1965680390 @default.
• W2015083544 cites W1969582355 @default.
• W2015083544 cites W1982036700 @default.
• W2015083544 cites W1996791655 @default.
• W2015083544 cites W2003271961 @default.
• W2015083544 cites W2009707750 @default.
• W2015083544 cites W2013795083 @default.
• W2015083544 cites W2013950135 @default.
• W2015083544 cites W2015336716 @default.
• W2015083544 cites W2020030703 @default.
• W2015083544 cites W2038504522 @default.
• W2015083544 cites W2038963685 @default.
• W2015083544 cites W2050742125 @default.
• W2015083544 cites W2078603396 @default.
• W2015083544 cites W2081098333 @default.
• W2015083544 cites W2081595143 @default.
• W2015083544 cites W2106608030 @default.
• W2015083544 cites W2107742275 @default.
• W2015083544 cites W2110646133 @default.
• W2015083544 cites W2118148287 @default.
• W2015083544 cites W2134220011 @default.
• W2015083544 cites W2166715647 @default.
• W2015083544 doi "https://doi.org/10.1111/ced.12256" @default.
• W2015083544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24450605" @default.
• W2015083544 hasPublicationYear "2014" @default.
• W2015083544 type Work @default.
• W2015083544 sameAs 2015083544 @default.
• W2015083544 citedByCount "13" @default.
• W2015083544 countsByYear W20150835442014 @default.
• W2015083544 countsByYear W20150835442017 @default.
• W2015083544 countsByYear W20150835442018 @default.
• W2015083544 countsByYear W20150835442019 @default.
• W2015083544 countsByYear W20150835442020 @default.
• W2015083544 countsByYear W20150835442021 @default.
• W2015083544 countsByYear W20150835442023 @default.
• W2015083544 crossrefType "journal-article" @default.
• W2015083544 hasAuthorship W2015083544A5007252427 @default.
• W2015083544 hasAuthorship W2015083544A5013661223 @default.
• W2015083544 hasAuthorship W2015083544A5030623879 @default.
• W2015083544 hasAuthorship W2015083544A5050511886 @default.
• W2015083544 hasAuthorship W2015083544A5060928869 @default.
• W2015083544 hasConcept C105702510 @default.
• W2015083544 hasConcept C1122143 @default.
• W2015083544 hasConcept C126322002 @default.
• W2015083544 hasConcept C159545944 @default.
• W2015083544 hasConcept C164027704 @default.
• W2015083544 hasConcept C170493617 @default.
• W2015083544 hasConcept C202751555 @default.
• W2015083544 hasConcept C203014093 @default.
• W2015083544 hasConcept C2776458125 @default.
• W2015083544 hasConcept C2776885963 @default.
• W2015083544 hasConcept C2776914184 @default.
• W2015083544 hasConcept C2777074287 @default.
• W2015083544 hasConcept C2780269544 @default.
• W2015083544 hasConcept C30862142 @default.
• W2015083544 hasConcept C34400551 @default.
• W2015083544 hasConcept C502942594 @default.
• W2015083544 hasConcept C55493867 @default.
• W2015083544 hasConcept C71924100 @default.
• W2015083544 hasConcept C86803240 @default.
• W2015083544 hasConcept C98274493 @default.
• W2015083544 hasConceptScore W2015083544C105702510 @default.
• W2015083544 hasConceptScore W2015083544C1122143 @default.
• W2015083544 hasConceptScore W2015083544C126322002 @default.
• W2015083544 hasConceptScore W2015083544C159545944 @default.
• W2015083544 hasConceptScore W2015083544C164027704 @default.
• W2015083544 hasConceptScore W2015083544C170493617 @default.
• W2015083544 hasConceptScore W2015083544C202751555 @default.
• W2015083544 hasConceptScore W2015083544C203014093 @default.
• W2015083544 hasConceptScore W2015083544C2776458125 @default.
• W2015083544 hasConceptScore W2015083544C2776885963 @default.
• W2015083544 hasConceptScore W2015083544C2776914184 @default.
• W2015083544 hasConceptScore W2015083544C2777074287 @default.
• W2015083544 hasConceptScore W2015083544C2780269544 @default.
• W2015083544 hasConceptScore W2015083544C30862142 @default.
• W2015083544 hasConceptScore W2015083544C34400551 @default.
• W2015083544 hasConceptScore W2015083544C502942594 @default.
• W2015083544 hasConceptScore W2015083544C55493867 @default.
• W2015083544 hasConceptScore W2015083544C71924100 @default.
• W2015083544 hasConceptScore W2015083544C86803240 @default.
• W2015083544 hasConceptScore W2015083544C98274493 @default.
• W2015083544 hasIssue "2" @default.
• W2015083544 hasLocation W20150835441 @default.
• W2015083544 hasLocation W20150835442 @default.

• next