FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015085004> ?p ?o ?g. }

• W2015085004 endingPage "12" @default.
• W2015085004 startingPage "1" @default.
• W2015085004 abstract "In the recent years, the discovery of a series of mutations in patients with myeloid malignancies has provided insight into the pathogenesis of myelodysplastic syndromes (MDSs), myeloproliferative neoplasms (MPNs), and acute myeloid leukemia (AML). Among these alterations have been mutations in genes, such as IDH1/2, TET2, DNMT3A, and EZH2, which appear to affect DNA and/or histone lysine methylation. Large clinical correlative studies are beginning to decipher the clinical importance, prevalence, and potential prognostic significance of these mutations. Additionally, burgeoning insight into the role of epigenetics in the pathogenesis of myeloid malignancies has prompted increased interest in development of novel therapies which target DNA and histone posttranslational modifications. DNA demethylating agents have been demonstrated to be clinically active in a subset of patients with MDS and AML and are used extensively. However, newer, more specific agents which alter DNA and histone modification are under preclinical study and development and are likely to expand our therapeutic options for these diseases in the near future. Here, we review the current understanding of the clinical importance of these newly discovered mutations in AML and MDS patients. We also discuss exciting developments in DNA methyltransferase inhibitor strategies and the prospect of novel histone lysine methyltransferase inhibitors." @default.
• W2015085004 created "2016-06-24" @default.
• W2015085004 creator A5010057352 @default.
• W2015085004 creator A5049612841 @default.
• W2015085004 date "2012-01-01" @default.
• W2015085004 modified "2023-09-23" @default.
• W2015085004 title "Mutations in Epigenetic Modifiers in Myeloid Malignancies and the Prospect of Novel Epigenetic-Targeted Therapy" @default.
• W2015085004 cites W1963736125 @default.
• W2015085004 cites W1968677867 @default.
• W2015085004 cites W1972016428 @default.
• W2015085004 cites W1975267683 @default.
• W2015085004 cites W1976879878 @default.
• W2015085004 cites W1977729188 @default.
• W2015085004 cites W1978926685 @default.
• W2015085004 cites W1981463058 @default.
• W2015085004 cites W1989987919 @default.
• W2015085004 cites W1994281469 @default.
• W2015085004 cites W1995675594 @default.
• W2015085004 cites W1998598673 @default.
• W2015085004 cites W2001048063 @default.
• W2015085004 cites W2005458309 @default.
• W2015085004 cites W2008735740 @default.
• W2015085004 cites W2013154874 @default.
• W2015085004 cites W2014397327 @default.
• W2015085004 cites W2015469768 @default.
• W2015085004 cites W2024373518 @default.
• W2015085004 cites W2032882684 @default.
• W2015085004 cites W2039556247 @default.
• W2015085004 cites W2040827479 @default.
• W2015085004 cites W2041027929 @default.
• W2015085004 cites W2043216151 @default.
• W2015085004 cites W2043934142 @default.
• W2015085004 cites W2048670128 @default.
• W2015085004 cites W2053421436 @default.
• W2015085004 cites W2061578142 @default.
• W2015085004 cites W2068311105 @default.
• W2015085004 cites W2071324073 @default.
• W2015085004 cites W2073872690 @default.
• W2015085004 cites W2074534625 @default.
• W2015085004 cites W2075327666 @default.
• W2015085004 cites W2077981176 @default.
• W2015085004 cites W2078972833 @default.
• W2015085004 cites W2079392960 @default.
• W2015085004 cites W2080452140 @default.
• W2015085004 cites W2081204899 @default.
• W2015085004 cites W2082312262 @default.
• W2015085004 cites W2082592723 @default.
• W2015085004 cites W2083535257 @default.
• W2015085004 cites W2088621765 @default.
• W2015085004 cites W2089517211 @default.
• W2015085004 cites W2091607700 @default.
• W2015085004 cites W2094044442 @default.
• W2015085004 cites W2096008196 @default.
• W2015085004 cites W2097743943 @default.
• W2015085004 cites W2103989098 @default.
• W2015085004 cites W2106473110 @default.
• W2015085004 cites W2108664872 @default.
• W2015085004 cites W2109150359 @default.
• W2015085004 cites W2111041465 @default.
• W2015085004 cites W2111737305 @default.
• W2015085004 cites W2112129429 @default.
• W2015085004 cites W2112495947 @default.
• W2015085004 cites W2115400483 @default.
• W2015085004 cites W2118119661 @default.
• W2015085004 cites W2124951199 @default.
• W2015085004 cites W2126817554 @default.
• W2015085004 cites W2127738065 @default.
• W2015085004 cites W2128919238 @default.
• W2015085004 cites W2131072337 @default.
• W2015085004 cites W2131860315 @default.
• W2015085004 cites W2133148543 @default.
• W2015085004 cites W2134061682 @default.
• W2015085004 cites W2137103862 @default.
• W2015085004 cites W2139610636 @default.
• W2015085004 cites W2140929811 @default.
• W2015085004 cites W2143078369 @default.
• W2015085004 cites W2143297156 @default.
• W2015085004 cites W2147370638 @default.
• W2015085004 cites W2152496375 @default.
• W2015085004 cites W2155436639 @default.
• W2015085004 cites W2159578337 @default.
• W2015085004 cites W2159731673 @default.
• W2015085004 cites W2162619595 @default.
• W2015085004 cites W2163344214 @default.
• W2015085004 cites W2163583950 @default.
• W2015085004 cites W2168784615 @default.
• W2015085004 cites W2169172058 @default.
• W2015085004 cites W264127248 @default.
• W2015085004 cites W3147736188 @default.
• W2015085004 cites W4212766227 @default.
• W2015085004 cites W4231499941 @default.
• W2015085004 cites W43055999 @default.
• W2015085004 doi "https://doi.org/10.1155/2012/469592" @default.
• W2015085004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3145345" @default.
• W2015085004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21811504" @default.
• W2015085004 hasPublicationYear "2012" @default.
• W2015085004 type Work @default.
• W2015085004 sameAs 2015085004 @default.

• next