FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015091541> ?p ?o ?g. }

• W2015091541 endingPage "1077" @default.
• W2015091541 startingPage "1068" @default.
• W2015091541 abstract "SummaryDilated cardiomyopathy (DCM) is a leading cause of heart failure and the most frequent indication for heart transplantation in young patients. Probably >25% of DCM cases are of familial etiology. We report here genetic localization in a three-generation German family with 12 affected individuals with autosomal dominant familial DCM characterized by ventricular dilatation, impaired systolic function, and conduction disease. After exclusion of known DCM loci, we performed a whole-genome screen and detected linkage of DCM to chromosome 2q14-q22. Investigation of only affected individuals defines a 24-cM interval between markers D2S2224 and D2S2324; when unaffected individuals are also included, the critical region decreases to 11 cM between markers D2S2224 and D2S112, with a peak LOD score of 3.73 at recombination fraction 0 at D2S2339. The identification of an additional locus for familial autosomal dominant DCM underlines the genetic heterogeneity and may assist in the elucidation of the causes of this disease. Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the most frequent indication for heart transplantation in young patients. Probably >25% of DCM cases are of familial etiology. We report here genetic localization in a three-generation German family with 12 affected individuals with autosomal dominant familial DCM characterized by ventricular dilatation, impaired systolic function, and conduction disease. After exclusion of known DCM loci, we performed a whole-genome screen and detected linkage of DCM to chromosome 2q14-q22. Investigation of only affected individuals defines a 24-cM interval between markers D2S2224 and D2S2324; when unaffected individuals are also included, the critical region decreases to 11 cM between markers D2S2224 and D2S112, with a peak LOD score of 3.73 at recombination fraction 0 at D2S2339. The identification of an additional locus for familial autosomal dominant DCM underlines the genetic heterogeneity and may assist in the elucidation of the causes of this disease." @default.
• W2015091541 created "2016-06-24" @default.
• W2015091541 creator A5016932484 @default.
• W2015091541 creator A5018368368 @default.
• W2015091541 creator A5037320109 @default.
• W2015091541 creator A5054308820 @default.
• W2015091541 creator A5063447603 @default.
• W2015091541 creator A5069231715 @default.
• W2015091541 creator A5077027470 @default.
• W2015091541 creator A5082130600 @default.
• W2015091541 date "1999-10-01" @default.
• W2015091541 modified "2023-10-12" @default.
• W2015091541 title "Investigation of a Family with Autosomal Dominant Dilated Cardiomyopathy Defines a Novel Locus on Chromosome 2q14-q22" @default.
• W2015091541 cites W1534284551 @default.
• W2015091541 cites W1548115096 @default.
• W2015091541 cites W1593294300 @default.
• W2015091541 cites W1604929717 @default.
• W2015091541 cites W1718931754 @default.
• W2015091541 cites W1965265115 @default.
• W2015091541 cites W1972107478 @default.
• W2015091541 cites W1974145389 @default.
• W2015091541 cites W1974639843 @default.
• W2015091541 cites W1982332647 @default.
• W2015091541 cites W1985292788 @default.
• W2015091541 cites W1990126044 @default.
• W2015091541 cites W1996227662 @default.
• W2015091541 cites W2001696936 @default.
• W2015091541 cites W2015205573 @default.
• W2015091541 cites W2019166705 @default.
• W2015091541 cites W2021839309 @default.
• W2015091541 cites W2024335891 @default.
• W2015091541 cites W2032625271 @default.
• W2015091541 cites W2036145275 @default.
• W2015091541 cites W2041982853 @default.
• W2015091541 cites W2043226123 @default.
• W2015091541 cites W2057693551 @default.
• W2015091541 cites W2063677263 @default.
• W2015091541 cites W2068671266 @default.
• W2015091541 cites W2069159476 @default.
• W2015091541 cites W2070071827 @default.
• W2015091541 cites W2085199959 @default.
• W2015091541 cites W2092730584 @default.
• W2015091541 cites W2094763401 @default.
• W2015091541 cites W2113865982 @default.
• W2015091541 cites W2120158958 @default.
• W2015091541 cites W2129302503 @default.
• W2015091541 cites W2136448753 @default.
• W2015091541 cites W2138475139 @default.
• W2015091541 cites W2150861553 @default.
• W2015091541 cites W2154626777 @default.
• W2015091541 cites W2176715668 @default.
• W2015091541 cites W2315633478 @default.
• W2015091541 cites W2329687194 @default.
• W2015091541 cites W4238376026 @default.
• W2015091541 cites W4290979827 @default.
• W2015091541 doi "https://doi.org/10.1086/302580" @default.
• W2015091541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1288240" @default.
• W2015091541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10486326" @default.
• W2015091541 hasPublicationYear "1999" @default.
• W2015091541 type Work @default.
• W2015091541 sameAs 2015091541 @default.
• W2015091541 citedByCount "64" @default.
• W2015091541 countsByYear W20150915412012 @default.
• W2015091541 countsByYear W20150915412013 @default.
• W2015091541 countsByYear W20150915412014 @default.
• W2015091541 countsByYear W20150915412015 @default.
• W2015091541 countsByYear W20150915412016 @default.
• W2015091541 countsByYear W20150915412017 @default.
• W2015091541 crossrefType "journal-article" @default.
• W2015091541 hasAuthorship W2015091541A5016932484 @default.
• W2015091541 hasAuthorship W2015091541A5018368368 @default.
• W2015091541 hasAuthorship W2015091541A5037320109 @default.
• W2015091541 hasAuthorship W2015091541A5054308820 @default.
• W2015091541 hasAuthorship W2015091541A5063447603 @default.
• W2015091541 hasAuthorship W2015091541A5069231715 @default.
• W2015091541 hasAuthorship W2015091541A5077027470 @default.
• W2015091541 hasAuthorship W2015091541A5082130600 @default.
• W2015091541 hasBestOaLocation W20150915411 @default.
• W2015091541 hasConcept C104317684 @default.
• W2015091541 hasConcept C126322002 @default.
• W2015091541 hasConcept C142870003 @default.
• W2015091541 hasConcept C164705383 @default.
• W2015091541 hasConcept C2776383484 @default.
• W2015091541 hasConcept C2778198053 @default.
• W2015091541 hasConcept C2778797674 @default.
• W2015091541 hasConcept C2778849806 @default.
• W2015091541 hasConcept C2911091166 @default.
• W2015091541 hasConcept C54355233 @default.
• W2015091541 hasConcept C71924100 @default.
• W2015091541 hasConcept C84597430 @default.
• W2015091541 hasConcept C86803240 @default.
• W2015091541 hasConceptScore W2015091541C104317684 @default.
• W2015091541 hasConceptScore W2015091541C126322002 @default.
• W2015091541 hasConceptScore W2015091541C142870003 @default.
• W2015091541 hasConceptScore W2015091541C164705383 @default.
• W2015091541 hasConceptScore W2015091541C2776383484 @default.
• W2015091541 hasConceptScore W2015091541C2778198053 @default.
• W2015091541 hasConceptScore W2015091541C2778797674 @default.

• next