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• W2015093089 abstract "Antibody-based immunoconjugates are specifically targeted monoclonal antibodies that deliver a cytotoxic payload to their target. The cytotoxic agents can be highly potent drugs, radionuclides or toxins. Such molecules, referred to as antibody–drug conjugates, radioimmunoconjugates and immunotoxins, respectively, represent a promising approach for enhancing the efficacy of unconjugated (naked) antibodies for improved therapeutic results. Though tremendous progress has been achieved over the last few decades, the safety of these molecules still remains a matter of concern and a careful design is required for achieving a relatively safe toxicity profile along with therapeutic effectiveness. This review focuses on the toxicities arising from the use of these potent agents." @default.
• W2015093089 created "2016-06-24" @default.
• W2015093089 creator A5013377891 @default.
• W2015093089 date "1984-01-01" @default.
• W2015093089 modified "2023-09-27" @default.
• W2015093089 title "Monoclonal antibodies in the treatment of cancer" @default.
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• W2015093089 doi "https://doi.org/10.1016/s1040-8428(84)80008-6" @default.
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