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- W2015094920 abstract "Apparently anomalous behaviour arises if a radiolabelled drug and a non-radioactive drug compete for binding to a membrane-bound receptor when (a) there is severe depletion of the radiolabelled drug and (b) the non-radioactive drug binds to a heterogeneous population of binding sites. In extreme cases, binding of the non-radioactive drug to the sites of high affinity can be obscured completely. This phenomenon is illustrated by the binding of carbachol to muscarinic receptors, estimated by inhibition of a radiolabelled antagonist." @default.
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- W2015094920 date "1980-10-15" @default.
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- W2015094920 title "Competitive binding studies with multiple sites Effects arising from depletion of the free radioligand" @default.
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- W2015094920 doi "https://doi.org/10.1016/0304-4165(80)90242-1" @default.
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