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- W2015095769 abstract "Chronic liver disease and hepatocellular carcinoma due to chronic hepatitis B virus (HBV) infection pose a major public health problem in highly endemic regions. Effective vaccines against HBV exist but more than 370 million people remain chronically infected with HBV For these patients there is a high risk to develop cirrhosis and hepatocellular carcinoma. Currently available therapies fail to control viral replication in the long term in most patients. Viral persistence has been associated with a defect in the development of HBV specific cellular immunity. Strategies to boost or to broaden the weak virus-specific T-cell response of patients with chronic hepatitis B have been proposed as a means of curing this persistent infection. HBV envelope- and nucleocapsid-based vaccines, new formulations for recombinant vaccines and DNA-based vaccines are currently being assessed in clinical trials. Improvements are clearly required, but vaccination is likely to be the cheapest and potentially most beneficial treatment." @default.
- W2015095769 created "2016-06-24" @default.
- W2015095769 creator A5060535660 @default.
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- W2015095769 date "2005-12-01" @default.
- W2015095769 modified "2023-09-23" @default.
- W2015095769 title "Therapeutic vaccination against chronic hepatitis B virus infection" @default.
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- W2015095769 doi "https://doi.org/10.1016/s1386-6532(05)80019-8" @default.
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