FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015096089> ?p ?o ?g. }

• W2015096089 endingPage "522" @default.
• W2015096089 startingPage "516" @default.
• W2015096089 abstract "Isolated segments of guinea‐pig trachea or perfused tracheal tubes were arranged for the recording of trachealis tension changes in Krebs solution containing indomethacin (2.8 μ m ). In opened tracheal segments, epithelium removal caused modest (2–3 fold) potentiation of the effects of acetylcholine (ACh) and methacholine (MeCh) but failed to potentiate carbachol (CCh), bethanechol (BeCh), oxotremorine or KCl. Pretreatment with ecothiopate potentiated effects of ACh and MeCh but not of CCh or BeCh. Removal of epithelium in ecothiopate‐treated tissue potentiated effects of ACh and MeCh but not of CCh or BeCh. Guinea‐pig ileum challenged with ACh was used as a bioassay system for cholinesterase activity. Scrapings of tracheal epithelium did not hydrolyse ACh. Histochemical staining revealed no fibres positive for acetylcholinesterase or pseudocholinesterase in the tracheal epithelium. However, the underlying tissues contained acetylcholinesterase‐positive nerve fibres and the trachealis muscle itself stained positively for pseudocholinesterase activity. Neither tetrodotoxin (3 μ m ) nor hexamethonium (500 μ m ) modified the ability of epithelium removal to potentiate ACh. In perfused tracheal tubes where spasmogens were added to the luminal perfusate, epithelium removal potentiated effects of ACh (31 fold), CCh (10 fold), oxotremorine (2 fold) and KCl. In perfused tracheal tubes where spasmogens were added to the Krebs solution superfusing the adventitial surface of the tissue, epithelium removal significantly reduced the potency of CCh, oxotremorine and KCl. It is concluded that the selectivity and magnitude of the potentiation of cholinomimetics caused by epithelium removal depends on the route by which the cholinomimetic agent gains access to the trachealis muscle. The potentiation of acetic acid esters of choline seen in opened tracheal segments does not reflect the loss of epithelial cholinesterase activity and does not depend on the activity of nervous reflex arcs in the tracheal wall. The reduced potency of adventitially‐applied cholinomimetics and KCl seen in epithelium‐denuded tissue strongly suggests that the epithelium can moderate trachealis sensitivity to cholinomimetic agents not only by releasing epithelium‐derived relaxing factor but also by acting as a barrier to drug diffusion." @default.
• W2015096089 created "2016-06-24" @default.
• W2015096089 creator A5035027639 @default.
• W2015096089 creator A5044524403 @default.
• W2015096089 creator A5056427557 @default.
• W2015096089 creator A5072698130 @default.
• W2015096089 date "1990-07-01" @default.
• W2015096089 modified "2023-10-17" @default.
• W2015096089 title "The effects of epithelium removal on the actions of cholinomimetic drugs in opened segments and perfused tubular preparations of guinea-pig trachea" @default.
• W2015096089 cites W137485638 @default.
• W2015096089 cites W1657740120 @default.
• W2015096089 cites W1674867165 @default.
• W2015096089 cites W1889620018 @default.
• W2015096089 cites W1969819722 @default.
• W2015096089 cites W1975946551 @default.
• W2015096089 cites W1978963183 @default.
• W2015096089 cites W1981488900 @default.
• W2015096089 cites W2021051388 @default.
• W2015096089 cites W2058285287 @default.
• W2015096089 cites W2074353240 @default.
• W2015096089 cites W2269166353 @default.
• W2015096089 cites W2341069630 @default.
• W2015096089 cites W2345496543 @default.
• W2015096089 cites W2416177950 @default.
• W2015096089 cites W2463702953 @default.
• W2015096089 doi "https://doi.org/10.1111/j.1476-5381.1990.tb15839.x" @default.
• W2015096089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917774" @default.
• W2015096089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2390675" @default.
• W2015096089 hasPublicationYear "1990" @default.
• W2015096089 type Work @default.
• W2015096089 sameAs 2015096089 @default.
• W2015096089 citedByCount "54" @default.
• W2015096089 countsByYear W20150960892012 @default.
• W2015096089 countsByYear W20150960892015 @default.
• W2015096089 crossrefType "journal-article" @default.
• W2015096089 hasAuthorship W2015096089A5035027639 @default.
• W2015096089 hasAuthorship W2015096089A5044524403 @default.
• W2015096089 hasAuthorship W2015096089A5056427557 @default.
• W2015096089 hasAuthorship W2015096089A5072698130 @default.
• W2015096089 hasBestOaLocation W20150960892 @default.
• W2015096089 hasConcept C126322002 @default.
• W2015096089 hasConcept C134018914 @default.
• W2015096089 hasConcept C170493617 @default.
• W2015096089 hasConcept C185592680 @default.
• W2015096089 hasConcept C202870285 @default.
• W2015096089 hasConcept C24998067 @default.
• W2015096089 hasConcept C2775893369 @default.
• W2015096089 hasConcept C2775910092 @default.
• W2015096089 hasConcept C2776178081 @default.
• W2015096089 hasConcept C2777714996 @default.
• W2015096089 hasConcept C2778815084 @default.
• W2015096089 hasConcept C2778824757 @default.
• W2015096089 hasConcept C2778988552 @default.
• W2015096089 hasConcept C2780660124 @default.
• W2015096089 hasConcept C2781260171 @default.
• W2015096089 hasConcept C33789571 @default.
• W2015096089 hasConcept C529295009 @default.
• W2015096089 hasConcept C54355233 @default.
• W2015096089 hasConcept C55493867 @default.
• W2015096089 hasConcept C71924100 @default.
• W2015096089 hasConcept C86803240 @default.
• W2015096089 hasConcept C87568996 @default.
• W2015096089 hasConcept C98274493 @default.
• W2015096089 hasConceptScore W2015096089C126322002 @default.
• W2015096089 hasConceptScore W2015096089C134018914 @default.
• W2015096089 hasConceptScore W2015096089C170493617 @default.
• W2015096089 hasConceptScore W2015096089C185592680 @default.
• W2015096089 hasConceptScore W2015096089C202870285 @default.
• W2015096089 hasConceptScore W2015096089C24998067 @default.
• W2015096089 hasConceptScore W2015096089C2775893369 @default.
• W2015096089 hasConceptScore W2015096089C2775910092 @default.
• W2015096089 hasConceptScore W2015096089C2776178081 @default.
• W2015096089 hasConceptScore W2015096089C2777714996 @default.
• W2015096089 hasConceptScore W2015096089C2778815084 @default.
• W2015096089 hasConceptScore W2015096089C2778824757 @default.
• W2015096089 hasConceptScore W2015096089C2778988552 @default.
• W2015096089 hasConceptScore W2015096089C2780660124 @default.
• W2015096089 hasConceptScore W2015096089C2781260171 @default.
• W2015096089 hasConceptScore W2015096089C33789571 @default.
• W2015096089 hasConceptScore W2015096089C529295009 @default.
• W2015096089 hasConceptScore W2015096089C54355233 @default.
• W2015096089 hasConceptScore W2015096089C55493867 @default.
• W2015096089 hasConceptScore W2015096089C71924100 @default.
• W2015096089 hasConceptScore W2015096089C86803240 @default.
• W2015096089 hasConceptScore W2015096089C87568996 @default.
• W2015096089 hasConceptScore W2015096089C98274493 @default.
• W2015096089 hasIssue "3" @default.
• W2015096089 hasLocation W20150960891 @default.
• W2015096089 hasLocation W20150960892 @default.
• W2015096089 hasLocation W20150960893 @default.
• W2015096089 hasLocation W20150960894 @default.
• W2015096089 hasOpenAccess W2015096089 @default.
• W2015096089 hasPrimaryLocation W20150960891 @default.
• W2015096089 hasRelatedWork W1976520758 @default.
• W2015096089 hasRelatedWork W1982008450 @default.
• W2015096089 hasRelatedWork W1995511819 @default.
• W2015096089 hasRelatedWork W2057792084 @default.
• W2015096089 hasRelatedWork W2094046903 @default.

• next