Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015100350> ?p ?o ?g. }
- W2015100350 endingPage "176" @default.
- W2015100350 startingPage "171" @default.
- W2015100350 abstract "In order to evaluate the targeting potential of mouse monoclonal antibody ONS-M21 recognizing a human astrocytoma- and medulloblastoma-associated antigen, the internalization ability of this antibody and the selective cytotoxicity in the toxin-conjugated form were examined. Internalization assay with 125I-labeled ONS-M21 showed that about 20% of the total radioactivities was detected in the cellular fraction of human medulloblastoma cell line ONS-76 cells and that the reaction reached a plateau level in 30 min. To examine the selective delivery capacity of a high molecular substance in place of 125I, an immunotoxin was prepared with ricin A chain and ONS-M21 via disulfide bonds. A cytotoxic effect against ONS-76 cells was found with [3H]thymidine incorporation assay using the immunotoxin, but not against antigen-negative HuH-7 and SW480 cells. These results suggest that ONS-M21 could effectively deliver toxins, chemotherapeutic agents or radionuclei to malignant glioma specifically." @default.
- W2015100350 created "2016-06-24" @default.
- W2015100350 creator A5029475928 @default.
- W2015100350 creator A5041965520 @default.
- W2015100350 creator A5046288905 @default.
- W2015100350 creator A5047256984 @default.
- W2015100350 creator A5053284015 @default.
- W2015100350 creator A5055742440 @default.
- W2015100350 creator A5066581969 @default.
- W2015100350 creator A5077615899 @default.
- W2015100350 creator A5086192831 @default.
- W2015100350 date "1998-05-01" @default.
- W2015100350 modified "2023-10-18" @default.
- W2015100350 title "Internalization with high targeting potential of mouse monoclonal antibody ONS-M21 recognizing human malignant glioma antigen" @default.
- W2015100350 cites W1478973534 @default.
- W2015100350 cites W1723447072 @default.
- W2015100350 cites W1748987851 @default.
- W2015100350 cites W1964421702 @default.
- W2015100350 cites W1978211369 @default.
- W2015100350 cites W1978811864 @default.
- W2015100350 cites W1988312630 @default.
- W2015100350 cites W2005241199 @default.
- W2015100350 cites W2006063029 @default.
- W2015100350 cites W2024487196 @default.
- W2015100350 cites W2028773044 @default.
- W2015100350 cites W2029606592 @default.
- W2015100350 cites W2029991413 @default.
- W2015100350 cites W2036560693 @default.
- W2015100350 cites W2040244557 @default.
- W2015100350 cites W2041759695 @default.
- W2015100350 cites W2044800952 @default.
- W2015100350 cites W2055349933 @default.
- W2015100350 cites W2073577189 @default.
- W2015100350 cites W2079549733 @default.
- W2015100350 cites W2080276530 @default.
- W2015100350 cites W2086856670 @default.
- W2015100350 cites W2088925558 @default.
- W2015100350 cites W2113319880 @default.
- W2015100350 cites W2155436362 @default.
- W2015100350 cites W2169385094 @default.
- W2015100350 cites W2235245398 @default.
- W2015100350 cites W2240694582 @default.
- W2015100350 cites W2243155851 @default.
- W2015100350 cites W2397751512 @default.
- W2015100350 cites W2915078038 @default.
- W2015100350 doi "https://doi.org/10.1016/s0304-3835(98)00030-5" @default.
- W2015100350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9619874" @default.
- W2015100350 hasPublicationYear "1998" @default.
- W2015100350 type Work @default.
- W2015100350 sameAs 2015100350 @default.
- W2015100350 citedByCount "5" @default.
- W2015100350 countsByYear W20151003502014 @default.
- W2015100350 crossrefType "journal-article" @default.
- W2015100350 hasAuthorship W2015100350A5029475928 @default.
- W2015100350 hasAuthorship W2015100350A5041965520 @default.
- W2015100350 hasAuthorship W2015100350A5046288905 @default.
- W2015100350 hasAuthorship W2015100350A5047256984 @default.
- W2015100350 hasAuthorship W2015100350A5053284015 @default.
- W2015100350 hasAuthorship W2015100350A5055742440 @default.
- W2015100350 hasAuthorship W2015100350A5066581969 @default.
- W2015100350 hasAuthorship W2015100350A5077615899 @default.
- W2015100350 hasAuthorship W2015100350A5086192831 @default.
- W2015100350 hasConcept C109316439 @default.
- W2015100350 hasConcept C115085202 @default.
- W2015100350 hasConcept C139770010 @default.
- W2015100350 hasConcept C147483822 @default.
- W2015100350 hasConcept C1491633281 @default.
- W2015100350 hasConcept C153911025 @default.
- W2015100350 hasConcept C154317977 @default.
- W2015100350 hasConcept C159654299 @default.
- W2015100350 hasConcept C185592680 @default.
- W2015100350 hasConcept C202751555 @default.
- W2015100350 hasConcept C203014093 @default.
- W2015100350 hasConcept C2778227246 @default.
- W2015100350 hasConcept C2778556491 @default.
- W2015100350 hasConcept C2780789225 @default.
- W2015100350 hasConcept C502942594 @default.
- W2015100350 hasConcept C542903549 @default.
- W2015100350 hasConcept C55493867 @default.
- W2015100350 hasConcept C86803240 @default.
- W2015100350 hasConceptScore W2015100350C109316439 @default.
- W2015100350 hasConceptScore W2015100350C115085202 @default.
- W2015100350 hasConceptScore W2015100350C139770010 @default.
- W2015100350 hasConceptScore W2015100350C147483822 @default.
- W2015100350 hasConceptScore W2015100350C1491633281 @default.
- W2015100350 hasConceptScore W2015100350C153911025 @default.
- W2015100350 hasConceptScore W2015100350C154317977 @default.
- W2015100350 hasConceptScore W2015100350C159654299 @default.
- W2015100350 hasConceptScore W2015100350C185592680 @default.
- W2015100350 hasConceptScore W2015100350C202751555 @default.
- W2015100350 hasConceptScore W2015100350C203014093 @default.
- W2015100350 hasConceptScore W2015100350C2778227246 @default.
- W2015100350 hasConceptScore W2015100350C2778556491 @default.
- W2015100350 hasConceptScore W2015100350C2780789225 @default.
- W2015100350 hasConceptScore W2015100350C502942594 @default.
- W2015100350 hasConceptScore W2015100350C542903549 @default.
- W2015100350 hasConceptScore W2015100350C55493867 @default.
- W2015100350 hasConceptScore W2015100350C86803240 @default.