FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015101853> ?p ?o ?g. }

• W2015101853 endingPage "65" @default.
• W2015101853 startingPage "55" @default.
• W2015101853 abstract "Contextual control over drug relapse depends on the successful reconsolidation and retention of context-response–cocaine associations in long-term memory stores. The basolateral amygdala (BLA) plays a critical role in cocaine memory reconsolidation and subsequent drug context-induced cocaine-seeking behavior; however, less is known about the cellular mechanisms of this phenomenon. The present study evaluated the hypothesis that protein kinase A (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII) activation in the BLA is necessary for the reconsolidation of context-response–cocaine memories that promote subsequent drug context-induced cocaine-seeking behavior. Rats were trained to lever-press for cocaine infusions in a distinct context, followed by extinction training in a different context. Rats were then briefly re-exposed to the previously cocaine-paired context or an unpaired context in order to reactivate cocaine-related contextual memories and initiate their reconsolidation or to provide a similar behavioral experience without explicit cocaine-related memory reactivation, respectively. Immediately after this session, rats received bilateral microinfusions of vehicle, the PKA inhibitor, Rp-adenosine 3’,5’-cyclic monophosphorothioate triethylammonium salt (Rp-cAMPS), or the CaMKII inhibitor, KN-93, into the BLA or the posterior caudate putamen (anatomical control region). Rats were then tested for cocaine-seeking behavior (responses on the previously cocaine-paired lever) in the cocaine-paired context and the extinction context. Intra-BLA infusion of Rp-cAMPS, but not KN-93, following cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory reactivation-dependent fashion. PKA, but not CaMKII, activation in the BLA is critical for cocaine memory re-stabilization processes that facilitate subsequent drug context-induced instrumental cocaine-seeking behavior." @default.
• W2015101853 created "2016-06-24" @default.
• W2015101853 creator A5003871991 @default.
• W2015101853 creator A5003948634 @default.
• W2015101853 creator A5005265587 @default.
• W2015101853 creator A5010496598 @default.
• W2015101853 creator A5025092547 @default.
• W2015101853 creator A5086981091 @default.
• W2015101853 date "2013-07-20" @default.
• W2015101853 modified "2023-10-18" @default.
• W2015101853 title "Involvement of amygdalar protein kinase A, but not calcium/calmodulin-dependent protein kinase II, in the reconsolidation of cocaine-related contextual memories in rats" @default.
• W2015101853 cites W1608785134 @default.
• W2015101853 cites W1892150242 @default.
• W2015101853 cites W1964187962 @default.
• W2015101853 cites W1966533004 @default.
• W2015101853 cites W1971632191 @default.
• W2015101853 cites W1977444525 @default.
• W2015101853 cites W1979708002 @default.
• W2015101853 cites W1982333295 @default.
• W2015101853 cites W1983038420 @default.
• W2015101853 cites W1988182239 @default.
• W2015101853 cites W1992291166 @default.
• W2015101853 cites W1997551208 @default.
• W2015101853 cites W2006070286 @default.
• W2015101853 cites W2007653857 @default.
• W2015101853 cites W2012639972 @default.
• W2015101853 cites W2013717577 @default.
• W2015101853 cites W2013830299 @default.
• W2015101853 cites W2014388728 @default.
• W2015101853 cites W2015355755 @default.
• W2015101853 cites W2018162107 @default.
• W2015101853 cites W2018650416 @default.
• W2015101853 cites W2020273146 @default.
• W2015101853 cites W2022235619 @default.
• W2015101853 cites W2025868648 @default.
• W2015101853 cites W2030657755 @default.
• W2015101853 cites W2037057152 @default.
• W2015101853 cites W2041675118 @default.
• W2015101853 cites W2049517532 @default.
• W2015101853 cites W2049753507 @default.
• W2015101853 cites W2052313515 @default.
• W2015101853 cites W2065746508 @default.
• W2015101853 cites W2072570863 @default.
• W2015101853 cites W2073700464 @default.
• W2015101853 cites W2074354688 @default.
• W2015101853 cites W2076345622 @default.
• W2015101853 cites W2083922649 @default.
• W2015101853 cites W2086243992 @default.
• W2015101853 cites W2086356333 @default.
• W2015101853 cites W2086466465 @default.
• W2015101853 cites W2086615573 @default.
• W2015101853 cites W2092921174 @default.
• W2015101853 cites W2095152292 @default.
• W2015101853 cites W2096831964 @default.
• W2015101853 cites W2105460175 @default.
• W2015101853 cites W2112578371 @default.
• W2015101853 cites W2114465430 @default.
• W2015101853 cites W2126502833 @default.
• W2015101853 cites W2127553362 @default.
• W2015101853 cites W2128084417 @default.
• W2015101853 cites W2133859126 @default.
• W2015101853 cites W2136026605 @default.
• W2015101853 cites W2142650205 @default.
• W2015101853 cites W2160953695 @default.
• W2015101853 cites W2167696282 @default.
• W2015101853 cites W2172184241 @default.
• W2015101853 cites W2952527331 @default.
• W2015101853 doi "https://doi.org/10.1007/s00213-013-3203-9" @default.
• W2015101853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3852194" @default.
• W2015101853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23873418" @default.
• W2015101853 hasPublicationYear "2013" @default.
• W2015101853 type Work @default.
• W2015101853 sameAs 2015101853 @default.
• W2015101853 citedByCount "39" @default.
• W2015101853 countsByYear W20151018532014 @default.
• W2015101853 countsByYear W20151018532015 @default.
• W2015101853 countsByYear W20151018532016 @default.
• W2015101853 countsByYear W20151018532017 @default.
• W2015101853 countsByYear W20151018532018 @default.
• W2015101853 countsByYear W20151018532019 @default.
• W2015101853 countsByYear W20151018532020 @default.
• W2015101853 countsByYear W20151018532021 @default.
• W2015101853 countsByYear W20151018532022 @default.
• W2015101853 countsByYear W20151018532023 @default.
• W2015101853 crossrefType "journal-article" @default.
• W2015101853 hasAuthorship W2015101853A5003871991 @default.
• W2015101853 hasAuthorship W2015101853A5003948634 @default.
• W2015101853 hasAuthorship W2015101853A5005265587 @default.
• W2015101853 hasAuthorship W2015101853A5010496598 @default.
• W2015101853 hasAuthorship W2015101853A5025092547 @default.
• W2015101853 hasAuthorship W2015101853A5086981091 @default.
• W2015101853 hasBestOaLocation W20151018532 @default.
• W2015101853 hasConcept C101991246 @default.
• W2015101853 hasConcept C151730666 @default.
• W2015101853 hasConcept C15744967 @default.
• W2015101853 hasConcept C169760540 @default.
• W2015101853 hasConcept C184235292 @default.
• W2015101853 hasConcept C185592680 @default.

• next