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• W2015118547 abstract "<b><i>Objective:</i></b> To investigate the excitability of segmental and suprasegmental systems in patients with primary restless legs syndrome (pRLS) by measuring the cortical silent period (C-SP) and the peripheral silent period (P-SP). <b><i>Background:</i></b> There is some evidence that RLS may be the motor manifestation of normal CNS periodicity that becomes disinhibited under certain conditions. The mechanism of this disinhibition is unclear. <b><i>Design/Methods:</i></b> Ten patients with pRLS and 10 normal age-matched subjects were studied. The mixed nerve P-SP produced by electrical stimulation of the median and common peroneal nerves was recorded during maximal contraction of the abductor pollicis brevis (APB) and tibialis anterior (TA) muscles. The C-SP produced by a single magnetic shock to motor cortex at 150% of resting threshold was also measured during maximal contraction of the APB and TA muscles. The average of 5 to 10 trials at each site was obtained and compared using Student’s <i>t</i>-test. <b><i>Results:</i></b> Resting central motor threshold was not significantly different between pRLS patients and the control group. The average duration of the C-SP was shorter in the APB (74.5 ± 37.7 versus 129.56 ± 35.95 msec, <i>p</i> < 0.05) and TA (66.81 ± 25.63 versus 136.1 ± 40.35 msec, <i>p</i> < 0.05) in patients with pRLS. The P-SP duration, however, was not significantly different between two groups in either limb. <b><i>Conclusion:</i></b> The supraspinal inhibitory system is impaired in pRLS." @default.
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• W2015118547 date "1999-10-01" @default.
• W2015118547 modified "2023-10-11" @default.
• W2015118547 title "Changes in excitability of motor cortical circuitry in primary restless legs syndrome" @default.
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• W2015118547 doi "https://doi.org/10.1212/wnl.53.6.1201" @default.
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