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- W2015121408 abstract "Exposure to the major air pollutant ozone can aggravate asthma and other lung diseases. Our recent study in human volunteers has shown that the glutathione S-transferase Mu 1 (GSTM1)-null genotype is associated with increased airway neutrophilic inflammation induced by inhaled ozone. The aim of this study was to examine the effect of GSTM1 modulation on interleukin 8 (IL-8) production in ozone-exposed human bronchial epithelial cells (BEAS-2B) and the underlying mechanisms. Exposure of BEAS-2B cells to 0.4 ppm ozone for 4 h significantly increased IL-8 release, with a modest reduction in intracellular reduced glutathione (GSH). Ozone exposure induced reactive oxygen species (ROS) production and NF-κB activation. Pharmacological inhibition of NF-κB activation or mutation of the IL-8 promoter at the κB-binding site significantly blocked ozone-induced IL-8 production or IL-8 transcriptional activity, respectively. Knockdown of GSTM1 in BEAS-2B cells enhanced ozone-induced NF-κB activation and IL-8 production. Consistently, an ozone-induced overt increase in IL-8 production was detected in GSTM1-null primary human bronchial epithelial cells. In addition, supplementation with reduced GSH inhibited ozone-induced ROS production, NF-κB activation, and IL-8 production. Taken together, GSTM1 deficiency enhances ozone-induced IL-8 production, which is mediated by generated ROS and subsequent NF-κB activation in human bronchial epithelial cells." @default.
- W2015121408 created "2016-06-24" @default.
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- W2015121408 date "2011-07-01" @default.
- W2015121408 modified "2023-10-16" @default.
- W2015121408 title "GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone" @default.
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- W2015121408 cites W1964167504 @default.
- W2015121408 cites W1973632534 @default.
- W2015121408 cites W1974559428 @default.
- W2015121408 cites W1976382352 @default.
- W2015121408 cites W1980991974 @default.
- W2015121408 cites W1981378268 @default.
- W2015121408 cites W2000959063 @default.
- W2015121408 cites W2004772897 @default.
- W2015121408 cites W2005659566 @default.
- W2015121408 cites W2010716981 @default.
- W2015121408 cites W2011007912 @default.
- W2015121408 cites W2011181724 @default.
- W2015121408 cites W2011781801 @default.
- W2015121408 cites W2011911611 @default.
- W2015121408 cites W2018011543 @default.
- W2015121408 cites W2019459568 @default.
- W2015121408 cites W2020025471 @default.
- W2015121408 cites W2021035424 @default.
- W2015121408 cites W2023194483 @default.
- W2015121408 cites W2026929150 @default.
- W2015121408 cites W2032223601 @default.
- W2015121408 cites W2033528576 @default.
- W2015121408 cites W2046750894 @default.
- W2015121408 cites W2047194856 @default.
- W2015121408 cites W2050722279 @default.
- W2015121408 cites W2052447033 @default.
- W2015121408 cites W2053422299 @default.
- W2015121408 cites W2053516011 @default.
- W2015121408 cites W2054818442 @default.
- W2015121408 cites W2056351871 @default.
- W2015121408 cites W2066416311 @default.
- W2015121408 cites W2069601315 @default.
- W2015121408 cites W2070862181 @default.
- W2015121408 cites W2071507812 @default.
- W2015121408 cites W2076143421 @default.
- W2015121408 cites W2079089950 @default.
- W2015121408 cites W2079855907 @default.
- W2015121408 cites W2083331590 @default.
- W2015121408 cites W2090144383 @default.
- W2015121408 cites W2092067512 @default.
- W2015121408 cites W2092815406 @default.
- W2015121408 cites W2094863064 @default.
- W2015121408 cites W2099533892 @default.
- W2015121408 cites W2100843520 @default.
- W2015121408 cites W2102461900 @default.
- W2015121408 cites W2105407937 @default.
- W2015121408 cites W2109945923 @default.
- W2015121408 cites W2112872455 @default.
- W2015121408 cites W2116237065 @default.
- W2015121408 cites W2116298059 @default.
- W2015121408 cites W2118033333 @default.
- W2015121408 cites W2120305962 @default.
- W2015121408 cites W2122044177 @default.
- W2015121408 cites W2122904810 @default.
- W2015121408 cites W2123718154 @default.
- W2015121408 cites W2125941855 @default.
- W2015121408 cites W2127465067 @default.
- W2015121408 cites W2128810168 @default.
- W2015121408 cites W2129004308 @default.
- W2015121408 cites W2135134158 @default.
- W2015121408 cites W2140993050 @default.
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- W2015121408 cites W2147657681 @default.
- W2015121408 cites W2147921405 @default.
- W2015121408 cites W2148119611 @default.
- W2015121408 cites W2150782588 @default.
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- W2015121408 cites W2170247979 @default.
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- W2015121408 doi "https://doi.org/10.1016/j.freeradbiomed.2011.05.006" @default.
- W2015121408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3134273" @default.
- W2015121408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21621609" @default.
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