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- W2015128377 abstract "Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme." @default.
- W2015128377 created "2016-06-24" @default.
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- W2015128377 date "2012-03-30" @default.
- W2015128377 modified "2023-09-24" @default.
- W2015128377 title "Insight into the Rescue of Oxidized Soluble Guanylate Cyclase by the Activator Cinaciguat" @default.
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- W2015128377 doi "https://doi.org/10.1002/cbic.201100809" @default.
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