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• W2015131480 abstract "Estradiol (E2) is locally synthesized within the hippocampus in addition to the gonads. Rapid modulation of hippocampal synaptic plasticity by E2 is essential for synaptic regulation. Molecular mechanisms of modulation through synaptic estrogen receptor (ER) and its downstream signaling, however, have been still unknown. We investigated induction of LTP by the presence of E2 upon weak theta burst stimulation (weak-TBS) in CA1 region of adult male hippocampus. Since only weak-TBS did not induce full-LTP, weak-TBS was sub-threshold stimulation. We observed LTP induction by the presence of E2, after incubation of hippocampal slices with 10 nM E2 for 30 min, upon weak-TBS. This E2-induced LTP was blocked by ICI, an ER antagonist. This E2-LTP induction was inhibited by blocking Erk MAPK, PKA, PKC, PI3K, NR2B and CaMKII, individually, suggesting that Erk MAPK, PKA, PKC, PI3K and CaMKII may be involved in downstream signaling for activation of NMDA receptors. Interestingly, dihydrotestosterone suppressed the E2-LTP. We also investigated rapid changes of dendritic spines (=postsynapses) in response to E2, using hippocampal slices from adult male rats. We found 1 nM E2 increased the density of spines by approximately 1.3-fold within 2 h by imaging Lucifer Yellow-injected CA1 pyramidal neurons. The E2-induced spine increase was blocked by ICI. The increase in spines was suppressed by blocking PI3K, Erk MAPK, p38 MAPK, PKA, PKC, LIMK, CaMKII or calcineurin, individually. On the other hand, blocking JNK did not inhibit the E2-induced spine increase. Taken together, these results suggest that E2 rapidly induced LTP and also increased the spine density through kinase networks that are driven by synaptic ER. This article is part of a Special Issue entitled SI: Brain and Memory." @default.
• W2015131480 created "2016-06-24" @default.
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• W2015131480 date "2015-09-01" @default.
• W2015131480 modified "2023-10-09" @default.
• W2015131480 title "Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks" @default.
• W2015131480 cites W1481438484 @default.
• W2015131480 cites W1488634403 @default.
• W2015131480 cites W1564265454 @default.
• W2015131480 cites W1580592479 @default.
• W2015131480 cites W1589135618 @default.
• W2015131480 cites W1661647511 @default.
• W2015131480 cites W1786781528 @default.
• W2015131480 cites W1937085587 @default.
• W2015131480 cites W1950495015 @default.
• W2015131480 cites W1954468845 @default.
• W2015131480 cites W1969474756 @default.
• W2015131480 cites W1970227809 @default.
• W2015131480 cites W1975759742 @default.
• W2015131480 cites W1976917710 @default.
• W2015131480 cites W1977860760 @default.
• W2015131480 cites W1977993427 @default.
• W2015131480 cites W1979776217 @default.
• W2015131480 cites W1987916086 @default.
• W2015131480 cites W1988517541 @default.
• W2015131480 cites W1990540942 @default.
• W2015131480 cites W1990651762 @default.
• W2015131480 cites W1992246182 @default.
• W2015131480 cites W1994729616 @default.
• W2015131480 cites W1998072745 @default.
• W2015131480 cites W1998848644 @default.
• W2015131480 cites W2002639930 @default.
• W2015131480 cites W2004804237 @default.
• W2015131480 cites W2019747892 @default.
• W2015131480 cites W2030933765 @default.
• W2015131480 cites W2032679733 @default.
• W2015131480 cites W2034507604 @default.
• W2015131480 cites W2036149308 @default.
• W2015131480 cites W2038526081 @default.
• W2015131480 cites W2041910867 @default.
• W2015131480 cites W2043940811 @default.
• W2015131480 cites W2048947179 @default.
• W2015131480 cites W2053642343 @default.
• W2015131480 cites W2055237452 @default.
• W2015131480 cites W2060090078 @default.
• W2015131480 cites W2063315017 @default.
• W2015131480 cites W2067233342 @default.
• W2015131480 cites W2068492591 @default.
• W2015131480 cites W2069474330 @default.
• W2015131480 cites W2073899218 @default.
• W2015131480 cites W2076454448 @default.
• W2015131480 cites W2078679082 @default.
• W2015131480 cites W2078890238 @default.
• W2015131480 cites W2079590715 @default.
• W2015131480 cites W2083896329 @default.
• W2015131480 cites W2085410500 @default.
• W2015131480 cites W2085547973 @default.
• W2015131480 cites W2086262311 @default.
• W2015131480 cites W2089964981 @default.
• W2015131480 cites W2090604814 @default.
• W2015131480 cites W2093160885 @default.
• W2015131480 cites W2094202922 @default.
• W2015131480 cites W2096033277 @default.
• W2015131480 cites W2096873347 @default.
• W2015131480 cites W2100216755 @default.
• W2015131480 cites W2106760089 @default.
• W2015131480 cites W2110887671 @default.
• W2015131480 cites W2111375880 @default.
• W2015131480 cites W2112404418 @default.
• W2015131480 cites W2120032880 @default.
• W2015131480 cites W2121403142 @default.
• W2015131480 cites W2121848469 @default.
• W2015131480 cites W2123090800 @default.
• W2015131480 cites W2128270206 @default.
• W2015131480 cites W2130739181 @default.
• W2015131480 cites W2136249808 @default.
• W2015131480 cites W2138075904 @default.
• W2015131480 cites W2138331726 @default.
• W2015131480 cites W2138356880 @default.
• W2015131480 cites W2144779659 @default.
• W2015131480 cites W2146599264 @default.
• W2015131480 cites W2149140304 @default.
• W2015131480 cites W2149906678 @default.
• W2015131480 cites W2152110038 @default.
• W2015131480 cites W2157544511 @default.
• W2015131480 cites W2162400338 @default.
• W2015131480 cites W2209257886 @default.
• W2015131480 cites W2400570679 @default.

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