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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015145802> ?p ?o ?g. }

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• W2015145802 abstract "The initiation and maintenance of the immune response require a coordinated regulation of signal transduction pathways. Identifying the mechanisms by which these pathways are controlled and modulated is a significant goal of immunology. In the present report, we show a novel role for the zinc finger transcription factor Kruppel-like factor 4 (KLF4) in the modulation of the inflammatory immune response via its regulation of IL-6. We analyzed the role of KLF4 in the production of IL-6 by dendritic cells. Our data indicate that KLF4 can act in a dual function manner. It acts as a transcription factor in that it can bind to and activate the IL-6 promoter at specific binding sites. KLF4 also has a role in the chromatin remodeling of the IL-6 promoter in that cells deficient in KLF4 exhibited a relative hypoacetylation. These results indicate a molecular role for KLF4 in modulating the intensity of the inflammatory response and help to explain its pleiotropic role in different settings." @default.
• W2015145802 created "2016-06-24" @default.
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• W2015145802 date "2013-08-01" @default.
• W2015145802 modified "2023-10-14" @default.
• W2015145802 title "KLF4 Modulates Expression of IL-6 in Dendritic Cells via Both Promoter Activation and Epigenetic Modification" @default.
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• W2015145802 doi "https://doi.org/10.1074/jbc.m113.479576" @default.
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