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- W2015145997 abstract "This study investigates the rate of age-related dopamine D2 receptor loss as determined by positron emission tomography (PET) and 11C-raclopride and compares it with D2 loss previously estimated with 18F-N-methylspiroperidol (NMS). Dopamine D2 receptors were measured with 11C-raclopride in 24 healthy volunteers (24–73 years of age) using the ratio of the distribution volume in striatum to that in cerebellum (BmaxKd+1). The results were compared with those obtained in 20 healthy male volunteers (20–49 years of age) in whom D2 receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysis between age and dopamine D2 receptor availability were significant for both ligands. Estimates of dopamine D2 receptors loss per decade corresponded to 7.9% for the 11C-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D2 receptors that occurred relatively early in life (40 years of age)." @default.
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- W2015145997 title "Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol" @default.
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- W2015145997 doi "https://doi.org/10.1016/0925-4927(96)02809-0" @default.
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