Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015147573> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2015147573 abstract "It has been reported that activation of the GABAA receptor complex by different agents such as barbiturates and neurosteroids can negatively regulate the hypothalamopituitary-gonadal axis. Recently, an 86-amino acid polypeptide with high affinity for diazepam binding sites, termed diazepam-binding inhibitor (DBI), has been found in the rat brain. DBI as well as a peptide derived from DBI, the octadecaneuropeptide DBI[33-50] (ODN), can interact with the GABAA receptor complex. In order to investigate the role of these endogenous ligands for GABAA receptors on GnRH gene expression, we studied the effects of the acute administration (4 h before sacrifice) of ODN injected alone or in combination with the GABAA agonist muscimol on GnRH mRNA levels. Treatment with ODN produced a 31% decrease in the number of silver grains overlying labelled neurones. This effect was not modified by the concomitant administration of muscimol. The administration of the GABAA antagonist picrotoxin not only reversed the inhibitory effect of ODN but induced a 24% increase in the hybridization signal. This stimulating influence of picrotoxin was less striking (15% over control levels) when muscimol was administered with ODN. These data clearly indicate that a potential endogenous neuropeptide can positively interact with the GABAA receptor complex to modulate GnRH neuronal activity." @default.
- W2015147573 created "2016-06-24" @default.
- W2015147573 creator A5042069930 @default.
- W2015147573 creator A5069823168 @default.
- W2015147573 date "1995-06-01" @default.
- W2015147573 modified "2023-10-18" @default.
- W2015147573 title "Inhibitory effect of the potential endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), on gonadotropinreleasing hormone gene expression in the male rat brain" @default.
- W2015147573 doi "https://doi.org/10.1097/00001756-199506090-00031" @default.
- W2015147573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7670003" @default.
- W2015147573 hasPublicationYear "1995" @default.
- W2015147573 type Work @default.
- W2015147573 sameAs 2015147573 @default.
- W2015147573 citedByCount "18" @default.
- W2015147573 crossrefType "journal-article" @default.
- W2015147573 hasAuthorship W2015147573A5042069930 @default.
- W2015147573 hasAuthorship W2015147573A5069823168 @default.
- W2015147573 hasConcept C118303440 @default.
- W2015147573 hasConcept C126322002 @default.
- W2015147573 hasConcept C134018914 @default.
- W2015147573 hasConcept C16613235 @default.
- W2015147573 hasConcept C168258287 @default.
- W2015147573 hasConcept C170493617 @default.
- W2015147573 hasConcept C185592680 @default.
- W2015147573 hasConcept C2776175493 @default.
- W2015147573 hasConcept C2778173252 @default.
- W2015147573 hasConcept C2778409475 @default.
- W2015147573 hasConcept C2778938600 @default.
- W2015147573 hasConcept C2779188335 @default.
- W2015147573 hasConcept C2779324764 @default.
- W2015147573 hasConcept C44796713 @default.
- W2015147573 hasConcept C71924100 @default.
- W2015147573 hasConcept C86803240 @default.
- W2015147573 hasConcept C98274493 @default.
- W2015147573 hasConceptScore W2015147573C118303440 @default.
- W2015147573 hasConceptScore W2015147573C126322002 @default.
- W2015147573 hasConceptScore W2015147573C134018914 @default.
- W2015147573 hasConceptScore W2015147573C16613235 @default.
- W2015147573 hasConceptScore W2015147573C168258287 @default.
- W2015147573 hasConceptScore W2015147573C170493617 @default.
- W2015147573 hasConceptScore W2015147573C185592680 @default.
- W2015147573 hasConceptScore W2015147573C2776175493 @default.
- W2015147573 hasConceptScore W2015147573C2778173252 @default.
- W2015147573 hasConceptScore W2015147573C2778409475 @default.
- W2015147573 hasConceptScore W2015147573C2778938600 @default.
- W2015147573 hasConceptScore W2015147573C2779188335 @default.
- W2015147573 hasConceptScore W2015147573C2779324764 @default.
- W2015147573 hasConceptScore W2015147573C44796713 @default.
- W2015147573 hasConceptScore W2015147573C71924100 @default.
- W2015147573 hasConceptScore W2015147573C86803240 @default.
- W2015147573 hasConceptScore W2015147573C98274493 @default.
- W2015147573 hasLocation W20151475731 @default.
- W2015147573 hasLocation W20151475732 @default.
- W2015147573 hasOpenAccess W2015147573 @default.
- W2015147573 hasPrimaryLocation W20151475731 @default.
- W2015147573 hasRelatedWork W1963749835 @default.
- W2015147573 hasRelatedWork W1990625391 @default.
- W2015147573 hasRelatedWork W1999018764 @default.
- W2015147573 hasRelatedWork W2006752825 @default.
- W2015147573 hasRelatedWork W2038659147 @default.
- W2015147573 hasRelatedWork W2041292328 @default.
- W2015147573 hasRelatedWork W2053876752 @default.
- W2015147573 hasRelatedWork W2065292749 @default.
- W2015147573 hasRelatedWork W2094469890 @default.
- W2015147573 hasRelatedWork W2110778161 @default.
- W2015147573 isParatext "false" @default.
- W2015147573 isRetracted "false" @default.
- W2015147573 magId "2015147573" @default.
- W2015147573 workType "article" @default.