FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015148235> ?p ?o ?g. }

• W2015148235 endingPage "466" @default.
• W2015148235 startingPage "458" @default.
• W2015148235 abstract "The adrenal steroid hormones, glucocorticoids, control many physiological responses to trauma, including elevated synthesis of fibrinogen, a major blood-clotting protein. Glucocorticoid regulation of the gamma-fibrinogen subunit gene in Xenopus laevis is mediated by a binding site for Xenopus glucocorticoid receptor accessory factor (XGRAF) and a contiguous glucocorticoid response element (GRE) half-site. Here, we characterize the protein:DNA complex formed by a cooperative interaction between XGRAF, GR, and the DNA. We demonstrate that the complex contains XGRAF by competition in a gel shift assay. The presence of GR is established by two criteria: 1) size dependence of the XGRAF:GR:DNA complex on the size of the GR component and 2) interference with complex formation by GR antibody. Cooperative binding of XGRAF and GR to the DNA was quantitated, showing that GR favors binding to XGRAF:DNA compared with free DNA by a factor of 30. The cooperative interaction between XGRAF and GR can occur on nicked DNA but is disrupted when 1 bp is inserted between the XGRAF binding site and half-GRE. Significantly, this loss of physical association in vitro correlates with loss of XGRAF amplification of GR activity in transiently transfected primary Xenopus hepatocytes. The simplest explanation for cooperativity between XGRAF and GR is formation of a DNA-bound heterodimer of these two proteins. This mechanism represents a new mode of transcriptional regulation in which GR and a nonreceptor protein form a heterodimer, with both partners contacting their specific DNA sites simultaneously." @default.
• W2015148235 created "2016-06-24" @default.
• W2015148235 creator A5069992441 @default.
• W2015148235 creator A5082707932 @default.
• W2015148235 creator A5085355773 @default.
• W2015148235 creator A5089092205 @default.
• W2015148235 date "2001-03-01" @default.
• W2015148235 modified "2023-10-17" @default.
• W2015148235 title "Heterodimerization between the Glucocorticoid Receptor and the Unrelated DNA-Binding Protein,XenopusGlucocorticoid Receptor Accessory Factor" @default.
• W2015148235 cites W1509565492 @default.
• W2015148235 cites W1551136566 @default.
• W2015148235 cites W1554294376 @default.
• W2015148235 cites W1775297890 @default.
• W2015148235 cites W1968905365 @default.
• W2015148235 cites W1986368022 @default.
• W2015148235 cites W1989041945 @default.
• W2015148235 cites W1997510672 @default.
• W2015148235 cites W2000400976 @default.
• W2015148235 cites W2003196551 @default.
• W2015148235 cites W2018499187 @default.
• W2015148235 cites W2030110709 @default.
• W2015148235 cites W2035415315 @default.
• W2015148235 cites W2041781038 @default.
• W2015148235 cites W2048327622 @default.
• W2015148235 cites W2048670847 @default.
• W2015148235 cites W2058081875 @default.
• W2015148235 cites W2071263028 @default.
• W2015148235 cites W2071525868 @default.
• W2015148235 cites W2078001389 @default.
• W2015148235 cites W2084885861 @default.
• W2015148235 cites W2095437984 @default.
• W2015148235 cites W2095465583 @default.
• W2015148235 cites W2097237892 @default.
• W2015148235 cites W2119725374 @default.
• W2015148235 cites W2128840922 @default.
• W2015148235 cites W2132251976 @default.
• W2015148235 cites W2144634347 @default.
• W2015148235 cites W2158022708 @default.
• W2015148235 cites W2172256092 @default.
• W2015148235 cites W2180559065 @default.
• W2015148235 cites W2207136697 @default.
• W2015148235 cites W2605614532 @default.
• W2015148235 cites W2764384160 @default.
• W2015148235 doi "https://doi.org/10.1210/mend.15.3.0607" @default.
• W2015148235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11222746" @default.
• W2015148235 hasPublicationYear "2001" @default.
• W2015148235 type Work @default.
• W2015148235 sameAs 2015148235 @default.
• W2015148235 citedByCount "4" @default.
• W2015148235 crossrefType "journal-article" @default.
• W2015148235 hasAuthorship W2015148235A5069992441 @default.
• W2015148235 hasAuthorship W2015148235A5082707932 @default.
• W2015148235 hasAuthorship W2015148235A5085355773 @default.
• W2015148235 hasAuthorship W2015148235A5089092205 @default.
• W2015148235 hasBestOaLocation W20151482351 @default.
• W2015148235 hasConcept C104317684 @default.
• W2015148235 hasConcept C107824862 @default.
• W2015148235 hasConcept C121608353 @default.
• W2015148235 hasConcept C134018914 @default.
• W2015148235 hasConcept C153911025 @default.
• W2015148235 hasConcept C2779535977 @default.
• W2015148235 hasConcept C2780841215 @default.
• W2015148235 hasConcept C51445715 @default.
• W2015148235 hasConcept C530470458 @default.
• W2015148235 hasConcept C54355233 @default.
• W2015148235 hasConcept C552990157 @default.
• W2015148235 hasConcept C55493867 @default.
• W2015148235 hasConcept C59493245 @default.
• W2015148235 hasConcept C84606932 @default.
• W2015148235 hasConcept C86803240 @default.
• W2015148235 hasConcept C95444343 @default.
• W2015148235 hasConceptScore W2015148235C104317684 @default.
• W2015148235 hasConceptScore W2015148235C107824862 @default.
• W2015148235 hasConceptScore W2015148235C121608353 @default.
• W2015148235 hasConceptScore W2015148235C134018914 @default.
• W2015148235 hasConceptScore W2015148235C153911025 @default.
• W2015148235 hasConceptScore W2015148235C2779535977 @default.
• W2015148235 hasConceptScore W2015148235C2780841215 @default.
• W2015148235 hasConceptScore W2015148235C51445715 @default.
• W2015148235 hasConceptScore W2015148235C530470458 @default.
• W2015148235 hasConceptScore W2015148235C54355233 @default.
• W2015148235 hasConceptScore W2015148235C552990157 @default.
• W2015148235 hasConceptScore W2015148235C55493867 @default.
• W2015148235 hasConceptScore W2015148235C59493245 @default.
• W2015148235 hasConceptScore W2015148235C84606932 @default.
• W2015148235 hasConceptScore W2015148235C86803240 @default.
• W2015148235 hasConceptScore W2015148235C95444343 @default.
• W2015148235 hasIssue "3" @default.
• W2015148235 hasLocation W20151482351 @default.
• W2015148235 hasLocation W20151482352 @default.
• W2015148235 hasOpenAccess W2015148235 @default.
• W2015148235 hasPrimaryLocation W20151482351 @default.
• W2015148235 hasRelatedWork W1968154721 @default.
• W2015148235 hasRelatedWork W1971736105 @default.
• W2015148235 hasRelatedWork W1993466444 @default.
• W2015148235 hasRelatedWork W1993732217 @default.
• W2015148235 hasRelatedWork W1995796899 @default.
• W2015148235 hasRelatedWork W1998644619 @default.

• next