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• W2015149198 abstract "The P2X7 receptor (P2X7R) induces ionotropic Ca²⁺ signalling in different cell types. It plays an important role in the immune response and in the nervous system. Here, the mechanisms underlying intracellular Ca²⁺ variations evoked by 3'-O-(4-benzoyl)benzoyl-ATP (BzATP), a potent agonist of the P2X7R, in transfected HEK293 cells, are investigated both experimentally and theoretically. We propose a minimal model of P2X7R that is capable of reproducing, qualitatively and quantitatively, the experimental data. This approach was also adopted for the P2X7R variant, which lacks the entire C-terminus tail (trP2X7R). Then we introduce a biophysical model describing the Ca²⁺ dynamics in HEK293. Our model gives an account of the ionotropic Ca²⁺ influx evoked by BzATP on the basis of the kinetics model of P2X7R. To explain the complex Ca²⁺ responses evoked by BzATP, the model predicted that an impairment in Ca²⁺ extrusion flux through the plasma membrane is a key factor for Ca²⁺ homeostasis in HEK293 cells." @default.
• W2015149198 created "2016-06-24" @default.
• W2015149198 creator A5020191433 @default.
• W2015149198 creator A5038559219 @default.
• W2015149198 creator A5075992126 @default.
• W2015149198 date "2012-04-01" @default.
• W2015149198 modified "2023-09-23" @default.
• W2015149198 title "P2X7 receptor-mediated calcium dynamics in HEK293 cells: experimental characterization and modelling approach" @default.
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• W2015149198 doi "https://doi.org/10.1088/1478-3975/9/2/026001" @default.
• W2015149198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22473129" @default.
• W2015149198 hasPublicationYear "2012" @default.
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