FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015151908> ?p ?o ?g. }

• W2015151908 endingPage "581" @default.
• W2015151908 startingPage "574" @default.
• W2015151908 abstract "In previous studies we found that mu-opioids, acting via mu-opioid receptors, inhibit endothelin-stimulated C6 glioma cell growth. In the preceding article we show that the kappa-selective opioid agonist U69,593 acts as a mitogen with a potency similar to that of endothelin in the same astrocytic model system. Here we report that C6 cell treatment with mu-opioid agonists for 1 h results in the inhibition of kappa-opioid mitogenic signaling. The mu-selective agonist endomorphin-1 attenuates kappa-opioid-stimulated DNA synthesis, phosphoinositide turnover, and extracellular signal-regulated kinase phosphorylation. To investigate the role of receptor endocytosis in signaling, we have examined the effects of dynamin-1 and its GTPase-defective, dominant suppressor mutant (K44A) on opioid modulation of extracellular signal-regulated kinase phosphorylation in C6 cells. Overexpression of dynamin K44A in C6 cells does not affect kappa-opioid phosphorylation of extracellular signal-regulated kinase. However, it does block the inhibitory action on kappa-opioid signaling mediated by the kappa-opioid receptor. Our results are consistent with a growing body of evidence of the opposing actions of mu- and kappa-opioids and provide new insight into the role of opioid receptor trafficking in signaling." @default.
• W2015151908 created "2016-06-24" @default.
• W2015151908 creator A5003815380 @default.
• W2015151908 creator A5010320763 @default.
• W2015151908 creator A5024221688 @default.
• W2015151908 date "2001-12-25" @default.
• W2015151908 modified "2023-10-16" @default.
• W2015151908 title "μ-Opioid Agonist Inhibition of κ-Opioid Receptor-Stimulated Extracellular Signal-Regulated Kinase Phosphorylation Is Dynamin-Dependent in C6 Glioma Cells" @default.
• W2015151908 cites W1505938433 @default.
• W2015151908 cites W1918531995 @default.
• W2015151908 cites W1921249433 @default.
• W2015151908 cites W1947474096 @default.
• W2015151908 cites W1963817582 @default.
• W2015151908 cites W1970407380 @default.
• W2015151908 cites W1972812883 @default.
• W2015151908 cites W1975262853 @default.
• W2015151908 cites W1975386197 @default.
• W2015151908 cites W1976046184 @default.
• W2015151908 cites W1976391336 @default.
• W2015151908 cites W1978627586 @default.
• W2015151908 cites W1980445909 @default.
• W2015151908 cites W1983427128 @default.
• W2015151908 cites W1984536659 @default.
• W2015151908 cites W1993966541 @default.
• W2015151908 cites W1994353818 @default.
• W2015151908 cites W2001718156 @default.
• W2015151908 cites W2004120139 @default.
• W2015151908 cites W2010649861 @default.
• W2015151908 cites W2011357928 @default.
• W2015151908 cites W2011456572 @default.
• W2015151908 cites W2014211428 @default.
• W2015151908 cites W2014285566 @default.
• W2015151908 cites W2014950332 @default.
• W2015151908 cites W2019256001 @default.
• W2015151908 cites W2020898323 @default.
• W2015151908 cites W2021182851 @default.
• W2015151908 cites W2021403208 @default.
• W2015151908 cites W2042603562 @default.
• W2015151908 cites W2048741586 @default.
• W2015151908 cites W2050323310 @default.
• W2015151908 cites W2050420785 @default.
• W2015151908 cites W2051335785 @default.
• W2015151908 cites W2054148822 @default.
• W2015151908 cites W2054473433 @default.
• W2015151908 cites W2054922048 @default.
• W2015151908 cites W2056270504 @default.
• W2015151908 cites W2067698573 @default.
• W2015151908 cites W2069317020 @default.
• W2015151908 cites W2086866777 @default.
• W2015151908 cites W2089545735 @default.
• W2015151908 cites W2093521999 @default.
• W2015151908 cites W2107801352 @default.
• W2015151908 cites W2120046850 @default.
• W2015151908 cites W2123190981 @default.
• W2015151908 cites W2127424619 @default.
• W2015151908 cites W2131231507 @default.
• W2015151908 cites W2134487678 @default.
• W2015151908 cites W2142422715 @default.
• W2015151908 cites W2151312020 @default.
• W2015151908 doi "https://doi.org/10.1046/j.1471-4159.2000.740574.x" @default.
• W2015151908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2571950" @default.
• W2015151908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10646508" @default.
• W2015151908 hasPublicationYear "2001" @default.
• W2015151908 type Work @default.
• W2015151908 sameAs 2015151908 @default.
• W2015151908 citedByCount "43" @default.
• W2015151908 countsByYear W20151519082013 @default.
• W2015151908 countsByYear W20151519082014 @default.
• W2015151908 countsByYear W20151519082015 @default.
• W2015151908 countsByYear W20151519082017 @default.
• W2015151908 countsByYear W20151519082018 @default.
• W2015151908 countsByYear W20151519082020 @default.
• W2015151908 countsByYear W20151519082021 @default.
• W2015151908 countsByYear W20151519082023 @default.
• W2015151908 crossrefType "journal-article" @default.
• W2015151908 hasAuthorship W2015151908A5003815380 @default.
• W2015151908 hasAuthorship W2015151908A5010320763 @default.
• W2015151908 hasAuthorship W2015151908A5024221688 @default.
• W2015151908 hasBestOaLocation W20151519082 @default.
• W2015151908 hasConcept C156407911 @default.
• W2015151908 hasConcept C170493617 @default.
• W2015151908 hasConcept C185592680 @default.
• W2015151908 hasConcept C2778938600 @default.
• W2015151908 hasConcept C28005876 @default.
• W2015151908 hasConcept C55493867 @default.
• W2015151908 hasConcept C62478195 @default.
• W2015151908 hasConcept C86803240 @default.
• W2015151908 hasConcept C95444343 @default.
• W2015151908 hasConcept C98274493 @default.
• W2015151908 hasConceptScore W2015151908C156407911 @default.
• W2015151908 hasConceptScore W2015151908C170493617 @default.
• W2015151908 hasConceptScore W2015151908C185592680 @default.
• W2015151908 hasConceptScore W2015151908C2778938600 @default.
• W2015151908 hasConceptScore W2015151908C28005876 @default.
• W2015151908 hasConceptScore W2015151908C55493867 @default.
• W2015151908 hasConceptScore W2015151908C62478195 @default.
• W2015151908 hasConceptScore W2015151908C86803240 @default.
• W2015151908 hasConceptScore W2015151908C95444343 @default.

• next