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- W2015153105 abstract "Abstract Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. eRF1 recognizes nonsense codons UAA, UAG, and UGA, while eRF3 stimulates polypeptide release from the ribosome in a GTP‐ and eRF1‐dependent manner. In the yeast Saccharomyces cerevisiae , eRF1 and eRF3 are encoded by the SUP45 and SUP35 genes, respectively. Here we show that in yeast shortage of any one of the release factors was accompanied by a reduction in the levels of the other release factor and resulted in a substantial increase of nonsense codon readthrough. Besides, repression of the genes encoding these factors caused different effects on cell morphology. Repression of the SUP35 gene caused accumulation of cells of increased size with large buds. This was accompanied by the disappearance of actin cytoskeletal structures, impairment of the mitotic spindle structure, and defects in nuclei division and segregation in mitosis. The evolutionary conserved C‐terminal domain of eRF3 similar to the elongation factor EF‐1α was responsible for these effects. Repression of the SUP45 gene caused accumulation of unbudded cells with 2C and higher DNA content, indicating that DNA replication is uncoupled from budding. The data obtained suggest that eRF1 and eRF3 play additional, nontranslational roles in the yeast cell. Cell Motil. Cytoskeleton 52:161–173, 2002. © 2002 Wiley‐Liss, Inc." @default.
- W2015153105 created "2016-06-24" @default.
- W2015153105 creator A5001243891 @default.
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- W2015153105 date "2002-06-19" @default.
- W2015153105 modified "2023-10-07" @default.
- W2015153105 title "Yeast polypeptide chain release factors eRF1 and eRF3 are involved in cytoskeleton organization and cell cycle regulation" @default.
- W2015153105 cites W1521738036 @default.
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- W2015153105 cites W1905639620 @default.
- W2015153105 cites W1939575473 @default.
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- W2015153105 doi "https://doi.org/10.1002/cm.10040" @default.
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