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- W2015157659 abstract "Multiple neuroprotective agents have shown benefit for the treatment of acute spinal cord injury (SCI) in animal studies. However, clinical trials have, thus far, been uniformly disappointing. This review explores reasons for discrepancies between promising animal studies and disappointing clinical trials and potential barriers to extrapolation of research results from animals to humans. The three major barriers disclosed are: differences in injury type between laboratory-induced SCI and clinical SCI, difficulties in interpreting functional outcome in animals, and inter-species and interstrain differences in pathophysiology of SCI. These barriers can impair the effectiveness of animal models of SCI to predict human outcomes. While some of these barriers can be overcome, others are inherent to the animal models." @default.
- W2015157659 created "2016-06-24" @default.
- W2015157659 creator A5025761714 @default.
- W2015157659 creator A5072335933 @default.
- W2015157659 creator A5084022998 @default.
- W2015157659 date "2008-01-01" @default.
- W2015157659 modified "2023-09-25" @default.
- W2015157659 title "Animal Models in Spinal Cord Injury: A Review" @default.
- W2015157659 cites W1498734521 @default.
- W2015157659 cites W1518074015 @default.
- W2015157659 cites W1531378706 @default.
- W2015157659 cites W1613539742 @default.
- W2015157659 cites W1680536342 @default.
- W2015157659 cites W1779982979 @default.
- W2015157659 cites W1840731200 @default.
- W2015157659 cites W1963502032 @default.
- W2015157659 cites W1964007213 @default.
- W2015157659 cites W1968329600 @default.
- W2015157659 cites W1971891609 @default.
- W2015157659 cites W1976936488 @default.
- W2015157659 cites W1979541355 @default.
- W2015157659 cites W1981150185 @default.
- W2015157659 cites W1981556150 @default.
- W2015157659 cites W1983466986 @default.
- W2015157659 cites W1985107882 @default.
- W2015157659 cites W1986103307 @default.
- W2015157659 cites W1992222970 @default.
- W2015157659 cites W1994121618 @default.
- W2015157659 cites W1995414607 @default.
- W2015157659 cites W1995885732 @default.
- W2015157659 cites W1996965408 @default.
- W2015157659 cites W1999746412 @default.
- W2015157659 cites W1999997856 @default.
- W2015157659 cites W2000572053 @default.
- W2015157659 cites W2003232848 @default.
- W2015157659 cites W2003687276 @default.
- W2015157659 cites W2005840825 @default.
- W2015157659 cites W2006125298 @default.
- W2015157659 cites W2006359635 @default.
- W2015157659 cites W2008231906 @default.
- W2015157659 cites W2009005936 @default.
- W2015157659 cites W2009246119 @default.
- W2015157659 cites W2009374265 @default.
- W2015157659 cites W2012281233 @default.
- W2015157659 cites W2014586086 @default.
- W2015157659 cites W2014804210 @default.
- W2015157659 cites W2020405700 @default.
- W2015157659 cites W2023459875 @default.
- W2015157659 cites W2027721692 @default.
- W2015157659 cites W2029277615 @default.
- W2015157659 cites W2031365737 @default.
- W2015157659 cites W2033234296 @default.
- W2015157659 cites W2033605190 @default.
- W2015157659 cites W2034117088 @default.
- W2015157659 cites W2034962760 @default.
- W2015157659 cites W2035650810 @default.
- W2015157659 cites W2039219460 @default.
- W2015157659 cites W2039420382 @default.
- W2015157659 cites W2039809192 @default.
- W2015157659 cites W2040228586 @default.
- W2015157659 cites W2040871722 @default.
- W2015157659 cites W2040916401 @default.
- W2015157659 cites W2045570605 @default.
- W2015157659 cites W2046569869 @default.
- W2015157659 cites W2047369546 @default.
- W2015157659 cites W2048534671 @default.
- W2015157659 cites W2052425527 @default.
- W2015157659 cites W2058086020 @default.
- W2015157659 cites W2058411142 @default.
- W2015157659 cites W2059540966 @default.
- W2015157659 cites W2059580081 @default.
- W2015157659 cites W2059695385 @default.
- W2015157659 cites W2062937749 @default.
- W2015157659 cites W2066230430 @default.
- W2015157659 cites W2068633406 @default.
- W2015157659 cites W2071494502 @default.
- W2015157659 cites W2073485235 @default.
- W2015157659 cites W2073798781 @default.
- W2015157659 cites W2074600461 @default.
- W2015157659 cites W2075710212 @default.
- W2015157659 cites W2077398525 @default.
- W2015157659 cites W2079006646 @default.
- W2015157659 cites W2081057188 @default.
- W2015157659 cites W2083015477 @default.
- W2015157659 cites W2083929651 @default.
- W2015157659 cites W2084088703 @default.
- W2015157659 cites W2088620464 @default.
- W2015157659 cites W2090998971 @default.
- W2015157659 cites W2092400709 @default.
- W2015157659 cites W2093738970 @default.
- W2015157659 cites W2094482422 @default.
- W2015157659 cites W2095276960 @default.
- W2015157659 cites W2098036585 @default.
- W2015157659 cites W2099721284 @default.
- W2015157659 cites W2101346916 @default.
- W2015157659 cites W2107796444 @default.
- W2015157659 cites W2109862373 @default.
- W2015157659 cites W2117446394 @default.
- W2015157659 cites W2129516502 @default.
- W2015157659 cites W2129589572 @default.