FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015161799> ?p ?o ?g. }

• W2015161799 endingPage "706" @default.
• W2015161799 startingPage "701" @default.
• W2015161799 abstract "MicroRNAs may function to promote or suppress tumor development, depending on the cellular context. The important role of microRNAs in regulating molecular pathways underlying tumorigenesis has been emphasized in hepatocellular carcinoma (HCC). MicroRNAs regulate gene expression via post-transcriptional mechanisms by inhibiting translation or by degrading mRNA. In this study, we show that microRNA-1 (miR-1) and microRNA-499 (miR-499) are capable of repressing the expression of the ets1 proto-oncogene, which plays a fundamental role in the extracellular matrix (ECM) degradation, a process required for tumor cell invasion and migration. We used luciferase reporter assays to demonstrate that miR-1 and miR-499 target the 3' untranslated region (UTR) of ets1. Overexpression of miR-1 and miR-499 in HepG2 cells led to downregulation of ets1 mRNA and protein as assessed by quantitative reverse transcription PCR and western blot analysis. Furthermore, overexpression of miR-1 and miR-499 inhibited the invasion and migration of HepG2 cells in matrigel invasion and transwell migration assays, respectively. These results suggest that miR-1 and miR-499 may play an important role in the pathogenesis of HCC by regulating ets1." @default.
• W2015161799 created "2016-06-24" @default.
• W2015161799 creator A5000737913 @default.
• W2015161799 creator A5003799076 @default.
• W2015161799 creator A5017871162 @default.
• W2015161799 creator A5024101693 @default.
• W2015161799 creator A5075183274 @default.
• W2015161799 creator A5086632320 @default.
• W2015161799 creator A5088559244 @default.
• W2015161799 date "2012-06-01" @default.
• W2015161799 modified "2023-09-27" @default.
• W2015161799 title "MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells" @default.
• W2015161799 cites W125901892 @default.
• W2015161799 cites W1976304781 @default.
• W2015161799 cites W1978116541 @default.
• W2015161799 cites W1998393594 @default.
• W2015161799 cites W2002995168 @default.
• W2015161799 cites W2005782838 @default.
• W2015161799 cites W2014946489 @default.
• W2015161799 cites W2017352677 @default.
• W2015161799 cites W2030607381 @default.
• W2015161799 cites W2032173335 @default.
• W2015161799 cites W2039394834 @default.
• W2015161799 cites W2039528484 @default.
• W2015161799 cites W2040424539 @default.
• W2015161799 cites W2048603557 @default.
• W2015161799 cites W2055381895 @default.
• W2015161799 cites W2056353125 @default.
• W2015161799 cites W2070852614 @default.
• W2015161799 cites W2080809110 @default.
• W2015161799 cites W2081453778 @default.
• W2015161799 cites W2082214219 @default.
• W2015161799 cites W2082985735 @default.
• W2015161799 cites W2100793390 @default.
• W2015161799 cites W2111456931 @default.
• W2015161799 cites W2130979840 @default.
• W2015161799 cites W2137052325 @default.
• W2015161799 cites W2139992910 @default.
• W2015161799 cites W2149848115 @default.
• W2015161799 cites W2150536104 @default.
• W2015161799 cites W2162674813 @default.
• W2015161799 cites W2162769953 @default.
• W2015161799 cites W2317059134 @default.
• W2015161799 cites W4247483179 @default.
• W2015161799 doi "https://doi.org/10.3892/or.2012.1850" @default.
• W2015161799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22664953" @default.
• W2015161799 hasPublicationYear "2012" @default.
• W2015161799 type Work @default.
• W2015161799 sameAs 2015161799 @default.
• W2015161799 citedByCount "51" @default.
• W2015161799 countsByYear W20151617992013 @default.
• W2015161799 countsByYear W20151617992014 @default.
• W2015161799 countsByYear W20151617992015 @default.
• W2015161799 countsByYear W20151617992016 @default.
• W2015161799 countsByYear W20151617992017 @default.
• W2015161799 countsByYear W20151617992018 @default.
• W2015161799 countsByYear W20151617992019 @default.
• W2015161799 countsByYear W20151617992020 @default.
• W2015161799 countsByYear W20151617992021 @default.
• W2015161799 countsByYear W20151617992022 @default.
• W2015161799 countsByYear W20151617992023 @default.
• W2015161799 crossrefType "journal-article" @default.
• W2015161799 hasAuthorship W2015161799A5000737913 @default.
• W2015161799 hasAuthorship W2015161799A5003799076 @default.
• W2015161799 hasAuthorship W2015161799A5017871162 @default.
• W2015161799 hasAuthorship W2015161799A5024101693 @default.
• W2015161799 hasAuthorship W2015161799A5075183274 @default.
• W2015161799 hasAuthorship W2015161799A5086632320 @default.
• W2015161799 hasAuthorship W2015161799A5088559244 @default.
• W2015161799 hasBestOaLocation W20151617991 @default.
• W2015161799 hasConcept C104317684 @default.
• W2015161799 hasConcept C105580179 @default.
• W2015161799 hasConcept C121608353 @default.
• W2015161799 hasConcept C127561419 @default.
• W2015161799 hasConcept C145059251 @default.
• W2015161799 hasConcept C1491633281 @default.
• W2015161799 hasConcept C22667442 @default.
• W2015161799 hasConcept C2781018059 @default.
• W2015161799 hasConcept C29537977 @default.
• W2015161799 hasConcept C502942594 @default.
• W2015161799 hasConcept C54355233 @default.
• W2015161799 hasConcept C555283112 @default.
• W2015161799 hasConcept C86803240 @default.
• W2015161799 hasConcept C89604277 @default.
• W2015161799 hasConcept C95444343 @default.
• W2015161799 hasConceptScore W2015161799C104317684 @default.
• W2015161799 hasConceptScore W2015161799C105580179 @default.
• W2015161799 hasConceptScore W2015161799C121608353 @default.
• W2015161799 hasConceptScore W2015161799C127561419 @default.
• W2015161799 hasConceptScore W2015161799C145059251 @default.
• W2015161799 hasConceptScore W2015161799C1491633281 @default.
• W2015161799 hasConceptScore W2015161799C22667442 @default.
• W2015161799 hasConceptScore W2015161799C2781018059 @default.
• W2015161799 hasConceptScore W2015161799C29537977 @default.
• W2015161799 hasConceptScore W2015161799C502942594 @default.
• W2015161799 hasConceptScore W2015161799C54355233 @default.
• W2015161799 hasConceptScore W2015161799C555283112 @default.
• W2015161799 hasConceptScore W2015161799C86803240 @default.

• next