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• W2015161884 abstract "Efficient oxygen supply is a continuing challenge for the fabrication of successful tissue engineered constructs with clinical relevance. In an effort to enhance oxygen delivery we report the feasibility of using fluorinated zeolite particles embedded in three-dimensional (3-D) polyurethane scaffolds as novel oxygen vectors. First, 1H,1H,2H,2H-perfluorodecyltriethoxysilane was successfully coupled to zeolite framework particles to examine the dose-dependent dissolved oxygen concentration. Following this, the fluorinated-zeolite (FZ) particles were embedded in 3-D tissue engineering polyurethane scaffolds. Our data demonstrates an even distribution of FZ particles in the 3-D scaffolds without affecting the scaffold porosity or pore size. Human coronary artery smooth muscle cell (HCASMC) proliferation on FZ-containing polyurethane (PCU-FZ) scaffolds was significantly greater than on control scaffolds (P=0.05). Remarkably, cell infiltration depths on the PCU-FZ scaffolds was double that on PCU control scaffolds. Taken together, our data suggest the potential of PCU-FZ scaffolds for tissue engineering with enhanced oxygen delivery to cells." @default.
• W2015161884 created "2016-06-24" @default.
• W2015161884 creator A5010139412 @default.
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• W2015161884 creator A5082219077 @default.
• W2015161884 date "2011-10-01" @default.
• W2015161884 modified "2023-09-27" @default.
• W2015161884 title "Tissue engineering scaffolds containing embedded fluorinated-zeolite oxygen vectors" @default.
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• W2015161884 doi "https://doi.org/10.1016/j.actbio.2011.06.010" @default.
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