Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015163085> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2015163085 endingPage "AB60" @default.
- W2015163085 startingPage "AB60" @default.
- W2015163085 abstract "RATIONALE: Asthma is a chronic inflammatory disease and oxidative stress has been known to play an important role in the pathogenesis of asthma. Clusterin, a ubiquitous glycoprotein, is closely linked to various cellular functions to keep homeostasis. Clusterin has been also recognized as a sensitive biosensor responding to increased oxidative stress in other inflammatory diseases. To date, the role of clusterin has not been investigated in asthma. METHODS: Serum levels of clusterin were measured by enzyme-linked immunosorbent assays (ELISA) in 142 asthma patients and 33 age-matched healthy controls. In 37 treatment naïve patients, the levels before treatment were compared with those after treatment with ICS. Expression of clusterin in peripheral blood mononuclear cells (PBMCs) and supernatants of induced sputum were assessed by western blot analysis in some of the patients. In addition, expression of hyperoxidized peroxiredoxins in PBMC was also evaluated as a cellular marker indicating increased oxidative stress in cells. RESULTS: Serum levels of clusterin were increased in the patients with severe asthma showing lower pulmonary functions than those in normal controls and the levels were reduced after ICS treatment in the treatment naïve patients. The expression of clusterin in sputum and PBMCs were remarkably enhanced in asthma patients and showed a significant correlation with intracellular hyperoxidized peroxiredoxins of PBMCs. CONCLUSIONS: Clusterin may be a useful biomarker indicating the degree of oxidative stress in asthmatics and severity of the disease as well. Further studies should be needed to investigate the precise role of clusterin in the pathogenesis of asthma." @default.
- W2015163085 created "2016-06-24" @default.
- W2015163085 creator A5005343692 @default.
- W2015163085 creator A5008086607 @default.
- W2015163085 creator A5017173193 @default.
- W2015163085 creator A5030882776 @default.
- W2015163085 creator A5038093186 @default.
- W2015163085 date "2011-02-01" @default.
- W2015163085 modified "2023-09-27" @default.
- W2015163085 title "The Possible Role of Clusterin As a Biomarker Representing Increased Oxidative Stress in Asthma" @default.
- W2015163085 doi "https://doi.org/10.1016/j.jaci.2010.12.250" @default.
- W2015163085 hasPublicationYear "2011" @default.
- W2015163085 type Work @default.
- W2015163085 sameAs 2015163085 @default.
- W2015163085 citedByCount "0" @default.
- W2015163085 crossrefType "journal-article" @default.
- W2015163085 hasAuthorship W2015163085A5005343692 @default.
- W2015163085 hasAuthorship W2015163085A5008086607 @default.
- W2015163085 hasAuthorship W2015163085A5017173193 @default.
- W2015163085 hasAuthorship W2015163085A5030882776 @default.
- W2015163085 hasAuthorship W2015163085A5038093186 @default.
- W2015163085 hasBestOaLocation W20151630851 @default.
- W2015163085 hasConcept C126322002 @default.
- W2015163085 hasConcept C137061746 @default.
- W2015163085 hasConcept C142724271 @default.
- W2015163085 hasConcept C190283241 @default.
- W2015163085 hasConcept C202751555 @default.
- W2015163085 hasConcept C203014093 @default.
- W2015163085 hasConcept C2776042228 @default.
- W2015163085 hasConcept C2776151105 @default.
- W2015163085 hasConcept C2776301714 @default.
- W2015163085 hasConcept C2779476363 @default.
- W2015163085 hasConcept C2780942790 @default.
- W2015163085 hasConcept C2781069245 @default.
- W2015163085 hasConcept C2781197716 @default.
- W2015163085 hasConcept C55493867 @default.
- W2015163085 hasConcept C71924100 @default.
- W2015163085 hasConcept C86803240 @default.
- W2015163085 hasConceptScore W2015163085C126322002 @default.
- W2015163085 hasConceptScore W2015163085C137061746 @default.
- W2015163085 hasConceptScore W2015163085C142724271 @default.
- W2015163085 hasConceptScore W2015163085C190283241 @default.
- W2015163085 hasConceptScore W2015163085C202751555 @default.
- W2015163085 hasConceptScore W2015163085C203014093 @default.
- W2015163085 hasConceptScore W2015163085C2776042228 @default.
- W2015163085 hasConceptScore W2015163085C2776151105 @default.
- W2015163085 hasConceptScore W2015163085C2776301714 @default.
- W2015163085 hasConceptScore W2015163085C2779476363 @default.
- W2015163085 hasConceptScore W2015163085C2780942790 @default.
- W2015163085 hasConceptScore W2015163085C2781069245 @default.
- W2015163085 hasConceptScore W2015163085C2781197716 @default.
- W2015163085 hasConceptScore W2015163085C55493867 @default.
- W2015163085 hasConceptScore W2015163085C71924100 @default.
- W2015163085 hasConceptScore W2015163085C86803240 @default.
- W2015163085 hasIssue "2" @default.
- W2015163085 hasLocation W20151630851 @default.
- W2015163085 hasOpenAccess W2015163085 @default.
- W2015163085 hasPrimaryLocation W20151630851 @default.
- W2015163085 hasRelatedWork W2351226947 @default.
- W2015163085 hasRelatedWork W2359199095 @default.
- W2015163085 hasRelatedWork W2375180626 @default.
- W2015163085 hasRelatedWork W2385418199 @default.
- W2015163085 hasRelatedWork W2394298848 @default.
- W2015163085 hasRelatedWork W2554812991 @default.
- W2015163085 hasRelatedWork W3029429637 @default.
- W2015163085 hasRelatedWork W3030164439 @default.
- W2015163085 hasRelatedWork W3032540778 @default.
- W2015163085 hasRelatedWork W3148242620 @default.
- W2015163085 hasVolume "127" @default.
- W2015163085 isParatext "false" @default.
- W2015163085 isRetracted "false" @default.
- W2015163085 magId "2015163085" @default.
- W2015163085 workType "article" @default.