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• W2015163857 endingPage "954" @default.
• W2015163857 startingPage "942" @default.
• W2015163857 abstract "The characterization of cyclodextrin (CD)–drug interactions has encountered difficulties in the solid state, especially of amorphous state. However, recent advances in experimental techniques, such as X-ray diffraction, spectroscopy, thermal analysis, and solid-state nuclear magnetic resonance, as well as computational chemistry have provided new insights in this area. Furthermore, inclusion complexes have been found to originate from noncovalent interactions, such as van der Waals and hydrogen bonding. The formation of CD hydrates and inclusion complexes in the solid state is considered to only rely on intermolecular interactions, without any covalent bond rupture and formation in host and guest molecules. The presence of water molecules as special guests impacts on the solid-state arrangement of CD molecules, which makes this influence important to consider. Accordingly, this review presents an overview of recent work about the physicochemical characterization of CD–drug interactions in the solid state with a focus on the effect of water molecules on these interactions. The characterization of cyclodextrin (CD)–drug interactions has encountered difficulties in the solid state, especially of amorphous state. However, recent advances in experimental techniques, such as X-ray diffraction, spectroscopy, thermal analysis, and solid-state nuclear magnetic resonance, as well as computational chemistry have provided new insights in this area. Furthermore, inclusion complexes have been found to originate from noncovalent interactions, such as van der Waals and hydrogen bonding. The formation of CD hydrates and inclusion complexes in the solid state is considered to only rely on intermolecular interactions, without any covalent bond rupture and formation in host and guest molecules. The presence of water molecules as special guests impacts on the solid-state arrangement of CD molecules, which makes this influence important to consider. Accordingly, this review presents an overview of recent work about the physicochemical characterization of CD–drug interactions in the solid state with a focus on the effect of water molecules on these interactions." @default.
• W2015163857 created "2016-06-24" @default.
• W2015163857 creator A5003483588 @default.
• W2015163857 creator A5043422428 @default.
• W2015163857 creator A5045094416 @default.
• W2015163857 date "2015-03-01" @default.
• W2015163857 modified "2023-10-06" @default.
• W2015163857 title "Physicochemical Characterization of Cyclodextrin–Drug Interactions in the Solid State and the Effect of Water on These Interactions" @default.
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