Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015164124> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2015164124 endingPage "3048" @default.
- W2015164124 startingPage "3041" @default.
- W2015164124 abstract "The antidiabetic property of a formulation containing metformin hydrochloride and detarium gum has been evaluated in streptozotocin model of experimental rats. Both the gum and metformin hydrochloride possess antidiabetic properties to varying degrees. The pharmacokinetics of metformin from the mucoadhesive dosage forms indicated that for metformin alone, the area under the curve (AUC) values were 125.6 and 135.6 mgh/ml at 200 and 400 mg/kg BW, respectively. For the mucoadhesive products using the same dose levels, the AUCs were modified to 102.4 and 150.2 in detarium gum and 59.9 and 80.4 in NaCMC. The results indicate that detarium gum is a good excipient for the formulation of metformin mucoadhesive delivery systems when compared with NaCMC. The gum also showed promising antidiabetic effect and should be cautiously used as it may lead to depressed blood-glucose levels beyond the desired levels." @default.
- W2015164124 created "2016-06-24" @default.
- W2015164124 creator A5047327492 @default.
- W2015164124 creator A5065647386 @default.
- W2015164124 creator A5091761204 @default.
- W2015164124 date "2004-07-01" @default.
- W2015164124 modified "2023-09-30" @default.
- W2015164124 title "Pharmacodynamic–pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models" @default.
- W2015164124 cites W1959371767 @default.
- W2015164124 cites W1976687721 @default.
- W2015164124 cites W2002387147 @default.
- W2015164124 cites W2003574632 @default.
- W2015164124 cites W2007416511 @default.
- W2015164124 cites W2015157047 @default.
- W2015164124 cites W2023774171 @default.
- W2015164124 cites W2026921121 @default.
- W2015164124 cites W2036248379 @default.
- W2015164124 cites W2040424479 @default.
- W2015164124 cites W2083414386 @default.
- W2015164124 cites W2105562011 @default.
- W2015164124 cites W2123683638 @default.
- W2015164124 cites W2124288520 @default.
- W2015164124 cites W2129477287 @default.
- W2015164124 cites W2136667764 @default.
- W2015164124 cites W2315895230 @default.
- W2015164124 cites W4232427571 @default.
- W2015164124 cites W2068779886 @default.
- W2015164124 doi "https://doi.org/10.1016/j.biomaterials.2003.09.073" @default.
- W2015164124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14967537" @default.
- W2015164124 hasPublicationYear "2004" @default.
- W2015164124 type Work @default.
- W2015164124 sameAs 2015164124 @default.
- W2015164124 citedByCount "32" @default.
- W2015164124 countsByYear W20151641242012 @default.
- W2015164124 countsByYear W20151641242013 @default.
- W2015164124 countsByYear W20151641242014 @default.
- W2015164124 countsByYear W20151641242015 @default.
- W2015164124 countsByYear W20151641242016 @default.
- W2015164124 countsByYear W20151641242019 @default.
- W2015164124 countsByYear W20151641242020 @default.
- W2015164124 countsByYear W20151641242022 @default.
- W2015164124 countsByYear W20151641242023 @default.
- W2015164124 crossrefType "journal-article" @default.
- W2015164124 hasAuthorship W2015164124A5047327492 @default.
- W2015164124 hasAuthorship W2015164124A5065647386 @default.
- W2015164124 hasAuthorship W2015164124A5091761204 @default.
- W2015164124 hasConcept C111113717 @default.
- W2015164124 hasConcept C112705442 @default.
- W2015164124 hasConcept C134018914 @default.
- W2015164124 hasConcept C192562407 @default.
- W2015164124 hasConcept C2777239854 @default.
- W2015164124 hasConcept C2779280383 @default.
- W2015164124 hasConcept C2780323712 @default.
- W2015164124 hasConcept C2909500757 @default.
- W2015164124 hasConcept C555293320 @default.
- W2015164124 hasConcept C71924100 @default.
- W2015164124 hasConcept C98274493 @default.
- W2015164124 hasConceptScore W2015164124C111113717 @default.
- W2015164124 hasConceptScore W2015164124C112705442 @default.
- W2015164124 hasConceptScore W2015164124C134018914 @default.
- W2015164124 hasConceptScore W2015164124C192562407 @default.
- W2015164124 hasConceptScore W2015164124C2777239854 @default.
- W2015164124 hasConceptScore W2015164124C2779280383 @default.
- W2015164124 hasConceptScore W2015164124C2780323712 @default.
- W2015164124 hasConceptScore W2015164124C2909500757 @default.
- W2015164124 hasConceptScore W2015164124C555293320 @default.
- W2015164124 hasConceptScore W2015164124C71924100 @default.
- W2015164124 hasConceptScore W2015164124C98274493 @default.
- W2015164124 hasIssue "15" @default.
- W2015164124 hasLocation W20151641241 @default.
- W2015164124 hasLocation W20151641242 @default.
- W2015164124 hasOpenAccess W2015164124 @default.
- W2015164124 hasPrimaryLocation W20151641241 @default.
- W2015164124 hasRelatedWork W1850703972 @default.
- W2015164124 hasRelatedWork W2015164124 @default.
- W2015164124 hasRelatedWork W2129477287 @default.
- W2015164124 hasRelatedWork W2239072168 @default.
- W2015164124 hasRelatedWork W2368034700 @default.
- W2015164124 hasRelatedWork W2380703908 @default.
- W2015164124 hasRelatedWork W2388069209 @default.
- W2015164124 hasRelatedWork W2611950068 @default.
- W2015164124 hasRelatedWork W3163678818 @default.
- W2015164124 hasRelatedWork W2741891919 @default.
- W2015164124 hasVolume "25" @default.
- W2015164124 isParatext "false" @default.
- W2015164124 isRetracted "false" @default.
- W2015164124 magId "2015164124" @default.
- W2015164124 workType "article" @default.