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- W2015166285 abstract "This work describes the de-novo design of peptides that inhibit a broad range of plant pathogens. Four structurally different groups of peptides were developed that differ in size and position of their charged and hydrophobic clusters and were assayed for their ability to inhibit bacterial growth and fungal spore germination. Several peptides are highly active at concentrations between 0,1 and 1 µg/ml against plant pathogenic bacteria, such as Pseudomonas syringae, Pectobacterium carotovorum, and Xanthomonas vesicatoria. Importantly, no hemolytic activity could be detected for these peptides at concentrations up to 200 µg/ml. Moreover, the peptides are also active after spraying on the plant surface demonstrating a possible way of application. In sum, our designed peptides represent new antimicrobial agents and with the increasing demand for antimicrobial compounds for production of healthy food, these peptides might serve as templates for novel antibacterial and antifungal agents." @default.
- W2015166285 created "2016-06-24" @default.
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- W2015166285 date "2013-08-12" @default.
- W2015166285 modified "2023-10-14" @default.
- W2015166285 title "De-Novo Design of Antimicrobial Peptides for Plant Protection" @default.
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- W2015166285 doi "https://doi.org/10.1371/journal.pone.0071687" @default.
- W2015166285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3741113" @default.
- W2015166285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23951222" @default.
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