Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015170224> ?p ?o ?g. }
- W2015170224 endingPage "779" @default.
- W2015170224 startingPage "772" @default.
- W2015170224 abstract "Proteinuria is associated with adverse cardiovascular and renal outcomes that are not prevented by current treatments. Endothelin 1 promotes the development and progression of chronic kidney disease and associated cardiovascular disease. We, therefore, studied the effects of selective endothelin-A receptor antagonism in proteinuric chronic kidney disease patients, assessing proteinuria, blood pressure (BP), and arterial stiffness, key independent, surrogate markers of chronic kidney disease progression and cardiovascular disease risk. In a randomized, double-blind, 3-way crossover study, 27 subjects on recommended renoprotective treatment received 6 weeks of placebo, 100 mg once daily of sitaxsentan, and 30 mg once daily of nifedipine long acting. Twenty-four–hour proteinuria, protein:creatinine ratio, 24-hour ambulatory BP, and pulse wave velocity (as a measure of arterial stiffness) were measured at baseline and week 6 of each treatment. In 13 subjects, renal blood flow and glomerular filtration rate were assessed at baseline and week 6 of each period. Compared with placebo, sitaxsentan reduced 24-hour proteinuria (−0.56±0.20 g/d; P =0.0069), protein:creatinine ratio (−38±15 mg/mmol; P =0.0102), BP (−3.4±1.2 mm Hg; P =0.0069), and pulse wave velocity (−0.64±0.24 m/s; P =0.0052). Nifedipine matched the BP and pulse wave velocity reductions seen with sitaxsentan but did not reduce proteinuria. Sitaxsentan alone reduced both glomerular filtration rate and filtration fraction. It caused no clinically significant adverse effects. Endothelin-A receptor antagonism may provide additional cardiovascular and renal protection by reducing proteinuria, BP, and arterial stiffness in optimally treated chronic kidney disease subjects. The antiproteinuric effects of sitaxsentan likely relate to changes in BP and renal hemodynamics." @default.
- W2015170224 created "2016-06-24" @default.
- W2015170224 creator A5004215185 @default.
- W2015170224 creator A5011631797 @default.
- W2015170224 creator A5018060366 @default.
- W2015170224 creator A5046696016 @default.
- W2015170224 creator A5068846869 @default.
- W2015170224 creator A5081449769 @default.
- W2015170224 creator A5085998748 @default.
- W2015170224 creator A5046897692 @default.
- W2015170224 date "2011-04-01" @default.
- W2015170224 modified "2023-10-01" @default.
- W2015170224 title "Selective Endothelin-A Receptor Antagonism Reduces Proteinuria, Blood Pressure, and Arterial Stiffness in Chronic Proteinuric Kidney Disease" @default.
- W2015170224 cites W1978345826 @default.
- W2015170224 cites W1983539151 @default.
- W2015170224 cites W1988814980 @default.
- W2015170224 cites W1992109588 @default.
- W2015170224 cites W2003591994 @default.
- W2015170224 cites W2004857031 @default.
- W2015170224 cites W2008772631 @default.
- W2015170224 cites W2014259599 @default.
- W2015170224 cites W2017268330 @default.
- W2015170224 cites W2047390341 @default.
- W2015170224 cites W2050071967 @default.
- W2015170224 cites W2074636215 @default.
- W2015170224 cites W2081190720 @default.
- W2015170224 cites W2086334936 @default.
- W2015170224 cites W2096875294 @default.
- W2015170224 cites W2097240907 @default.
- W2015170224 cites W2098813953 @default.
- W2015170224 cites W2105790451 @default.
- W2015170224 cites W2110051876 @default.
- W2015170224 cites W2114369401 @default.
- W2015170224 cites W2117004007 @default.
- W2015170224 cites W2125914602 @default.
- W2015170224 cites W2132111488 @default.
- W2015170224 cites W2139968474 @default.
- W2015170224 cites W2143795731 @default.
- W2015170224 cites W2143923014 @default.
- W2015170224 cites W2145632481 @default.
- W2015170224 cites W2163370089 @default.
- W2015170224 cites W2336346210 @default.
- W2015170224 cites W3021250193 @default.
- W2015170224 doi "https://doi.org/10.1161/hypertensionaha.110.167486" @default.
- W2015170224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21357275" @default.
- W2015170224 hasPublicationYear "2011" @default.
- W2015170224 type Work @default.
- W2015170224 sameAs 2015170224 @default.
- W2015170224 citedByCount "132" @default.
- W2015170224 countsByYear W20151702242012 @default.
- W2015170224 countsByYear W20151702242013 @default.
- W2015170224 countsByYear W20151702242014 @default.
- W2015170224 countsByYear W20151702242015 @default.
- W2015170224 countsByYear W20151702242016 @default.
- W2015170224 countsByYear W20151702242017 @default.
- W2015170224 countsByYear W20151702242018 @default.
- W2015170224 countsByYear W20151702242019 @default.
- W2015170224 countsByYear W20151702242020 @default.
- W2015170224 countsByYear W20151702242021 @default.
- W2015170224 countsByYear W20151702242022 @default.
- W2015170224 countsByYear W20151702242023 @default.
- W2015170224 crossrefType "journal-article" @default.
- W2015170224 hasAuthorship W2015170224A5004215185 @default.
- W2015170224 hasAuthorship W2015170224A5011631797 @default.
- W2015170224 hasAuthorship W2015170224A5018060366 @default.
- W2015170224 hasAuthorship W2015170224A5046696016 @default.
- W2015170224 hasAuthorship W2015170224A5046897692 @default.
- W2015170224 hasAuthorship W2015170224A5068846869 @default.
- W2015170224 hasAuthorship W2015170224A5081449769 @default.
- W2015170224 hasAuthorship W2015170224A5085998748 @default.
- W2015170224 hasBestOaLocation W20151702241 @default.
- W2015170224 hasConcept C126322002 @default.
- W2015170224 hasConcept C126894567 @default.
- W2015170224 hasConcept C134018914 @default.
- W2015170224 hasConcept C159641895 @default.
- W2015170224 hasConcept C2775850156 @default.
- W2015170224 hasConcept C2778319312 @default.
- W2015170224 hasConcept C2778653478 @default.
- W2015170224 hasConcept C2779561371 @default.
- W2015170224 hasConcept C2780091579 @default.
- W2015170224 hasConcept C2780306776 @default.
- W2015170224 hasConcept C71924100 @default.
- W2015170224 hasConcept C84393581 @default.
- W2015170224 hasConceptScore W2015170224C126322002 @default.
- W2015170224 hasConceptScore W2015170224C126894567 @default.
- W2015170224 hasConceptScore W2015170224C134018914 @default.
- W2015170224 hasConceptScore W2015170224C159641895 @default.
- W2015170224 hasConceptScore W2015170224C2775850156 @default.
- W2015170224 hasConceptScore W2015170224C2778319312 @default.
- W2015170224 hasConceptScore W2015170224C2778653478 @default.
- W2015170224 hasConceptScore W2015170224C2779561371 @default.
- W2015170224 hasConceptScore W2015170224C2780091579 @default.
- W2015170224 hasConceptScore W2015170224C2780306776 @default.
- W2015170224 hasConceptScore W2015170224C71924100 @default.
- W2015170224 hasConceptScore W2015170224C84393581 @default.
- W2015170224 hasIssue "4" @default.
- W2015170224 hasLocation W20151702241 @default.
- W2015170224 hasLocation W20151702242 @default.