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- W2015174249 abstract "Nitric oxide (NO) affects almost every physiological process, including the regulation of sleep. There is strong evidence that NO plays an important role in rapid eye movement sleep (REMS) regulation. To further investigate the role of NO in sleep, we characterized spontaneous sleep in mice with targeted disruptions (knockout; KO) in the neuronal nitric oxide synthase (nNOS) or inducible (i)NOS genes. REMS in nNOS KO mice was substantially lower than that of their control mice. In contrast, the iNOS KO mice had significantly more REMS than their controls. Inducible NOS KO mice also had less non-REMS (NREMS) during the dark period. Results suggest that nNOS and iNOS play opposite roles in REMS regulation." @default.
- W2015174249 created "2016-06-24" @default.
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- W2015174249 date "2003-05-01" @default.
- W2015174249 modified "2023-10-13" @default.
- W2015174249 title "Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes" @default.
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- W2015174249 doi "https://doi.org/10.1016/s0006-8993(03)02484-3" @default.
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