FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015181639> ?p ?o ?g. }

• W2015181639 endingPage "44" @default.
• W2015181639 startingPage "33" @default.
• W2015181639 abstract "Fat intake alters mitochondrial lipid composition which can affect function. We used novel methodology to assess bioenergetics, including simultaneous ATP and reactive oxygen species (ROS) production, in liver and heart mitochondria of C57BL/6 mice fed diets of variant fatty acid content and saturation. Our methodology allowed us to clamp ADP concentration and membrane potential (ΔΨ) at fixed levels. Mice received a control diet for 17–19 weeks, a high-fat (HF) diet (60% lard) for 17–19 weeks, or HF for 12 weeks followed by 6–7 weeks of HF with 50% of fat as menhaden oil (MO) which is rich in n-3 fatty acids. ATP production was determined as conversion of 2-deoxyglucose to 2-deoxyglucose phosphate by NMR spectroscopy. Respiration and ATP production were significantly reduced at all levels of ADP and resultant clamped ΔΨ in liver mitochondria from mice fed HF compared to controls. At given ΔΨ, ROS production per mg mitochondrial protein, per unit respiration, or per ATP generated were greater for liver mitochondria of HF-fed mice compared to control or MO-fed mice. Moreover, these ROS metrics began to increase at a lower ΔΨ threshold. Similar, but less marked, changes were observed in heart mitochondria of HF-fed mice compared to controls. No changes in mitochondrial bioenergetics were observed in studies of separate mice fed HF versus control for only 12 weeks. In summary, HF feeding of sufficient duration impairs mitochondrial bioenergetics and is associated with a greater ROS “cost” of ATP production compared to controls. These effects are, in part, mitigated by MO." @default.
• W2015181639 created "2016-06-24" @default.
• W2015181639 creator A5019843903 @default.
• W2015181639 creator A5032808557 @default.
• W2015181639 creator A5051924004 @default.
• W2015181639 creator A5055273664 @default.
• W2015181639 creator A5084995284 @default.
• W2015181639 creator A5085849213 @default.
• W2015181639 date "2013-10-15" @default.
• W2015181639 modified "2023-10-05" @default.
• W2015181639 title "Dietary fat, fatty acid saturation and mitochondrial bioenergetics" @default.
• W2015181639 cites W1555916645 @default.
• W2015181639 cites W1971215002 @default.
• W2015181639 cites W1975620564 @default.
• W2015181639 cites W1980328627 @default.
• W2015181639 cites W1980573776 @default.
• W2015181639 cites W1986857790 @default.
• W2015181639 cites W1986956461 @default.
• W2015181639 cites W1992678387 @default.
• W2015181639 cites W1993844842 @default.
• W2015181639 cites W2000079439 @default.
• W2015181639 cites W2002529150 @default.
• W2015181639 cites W2004032341 @default.
• W2015181639 cites W2015717700 @default.
• W2015181639 cites W2033279283 @default.
• W2015181639 cites W2039848901 @default.
• W2015181639 cites W2049871526 @default.
• W2015181639 cites W2056015556 @default.
• W2015181639 cites W2059005429 @default.
• W2015181639 cites W2070805734 @default.
• W2015181639 cites W2072444935 @default.
• W2015181639 cites W2074622106 @default.
• W2015181639 cites W2079793296 @default.
• W2015181639 cites W2082176639 @default.
• W2015181639 cites W2083169221 @default.
• W2015181639 cites W2089382506 @default.
• W2015181639 cites W2089914094 @default.
• W2015181639 cites W2090734611 @default.
• W2015181639 cites W2105364942 @default.
• W2015181639 cites W2112638909 @default.
• W2015181639 cites W2124257762 @default.
• W2015181639 cites W2126091201 @default.
• W2015181639 cites W2126272143 @default.
• W2015181639 cites W2127853112 @default.
• W2015181639 cites W2132658079 @default.
• W2015181639 cites W2143419384 @default.
• W2015181639 cites W2169821755 @default.
• W2015181639 cites W2255238810 @default.
• W2015181639 cites W2322082839 @default.
• W2015181639 cites W2411240035 @default.
• W2015181639 cites W4254242360 @default.
• W2015181639 cites W4254779481 @default.
• W2015181639 doi "https://doi.org/10.1007/s10863-013-9530-z" @default.
• W2015181639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3955408" @default.
• W2015181639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24121995" @default.
• W2015181639 hasPublicationYear "2013" @default.
• W2015181639 type Work @default.
• W2015181639 sameAs 2015181639 @default.
• W2015181639 citedByCount "40" @default.
• W2015181639 countsByYear W20151816392014 @default.
• W2015181639 countsByYear W20151816392015 @default.
• W2015181639 countsByYear W20151816392016 @default.
• W2015181639 countsByYear W20151816392017 @default.
• W2015181639 countsByYear W20151816392018 @default.
• W2015181639 countsByYear W20151816392019 @default.
• W2015181639 countsByYear W20151816392020 @default.
• W2015181639 countsByYear W20151816392021 @default.
• W2015181639 countsByYear W20151816392022 @default.
• W2015181639 countsByYear W20151816392023 @default.
• W2015181639 crossrefType "journal-article" @default.
• W2015181639 hasAuthorship W2015181639A5019843903 @default.
• W2015181639 hasAuthorship W2015181639A5032808557 @default.
• W2015181639 hasAuthorship W2015181639A5051924004 @default.
• W2015181639 hasAuthorship W2015181639A5055273664 @default.
• W2015181639 hasAuthorship W2015181639A5084995284 @default.
• W2015181639 hasAuthorship W2015181639A5085849213 @default.
• W2015181639 hasBestOaLocation W20151816392 @default.
• W2015181639 hasConcept C100206155 @default.
• W2015181639 hasConcept C105702510 @default.
• W2015181639 hasConcept C126322002 @default.
• W2015181639 hasConcept C134018914 @default.
• W2015181639 hasConcept C182215343 @default.
• W2015181639 hasConcept C185592680 @default.
• W2015181639 hasConcept C28859421 @default.
• W2015181639 hasConcept C48349386 @default.
• W2015181639 hasConcept C543025807 @default.
• W2015181639 hasConcept C55493867 @default.
• W2015181639 hasConcept C71924100 @default.
• W2015181639 hasConcept C86803240 @default.
• W2015181639 hasConceptScore W2015181639C100206155 @default.
• W2015181639 hasConceptScore W2015181639C105702510 @default.
• W2015181639 hasConceptScore W2015181639C126322002 @default.
• W2015181639 hasConceptScore W2015181639C134018914 @default.
• W2015181639 hasConceptScore W2015181639C182215343 @default.
• W2015181639 hasConceptScore W2015181639C185592680 @default.
• W2015181639 hasConceptScore W2015181639C28859421 @default.
• W2015181639 hasConceptScore W2015181639C48349386 @default.
• W2015181639 hasConceptScore W2015181639C543025807 @default.

• next