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- W2015184348 abstract "Social play behavior is a characteristic, vigorous form of social interaction in young mammals. It is highly rewarding and thought to be of major importance for social and cognitive development. The neural substrates of social play are incompletely understood, but there is evidence to support a role for the prefrontal cortex (PFC) and striatum in this behavior. Using pharmacological inactivation methods, ie, infusions of GABA receptor agonists (baclofen and muscimol; B&M) or the AMPA/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), we investigated the involvement of several subregions of the medial PFC and striatum in social play. Inactivation of the prelimbic cortex, infralimbic cortex, and medial/ventral orbitofrontal cortex using B&M markedly reduced frequency and duration of social play behavior. Local administration of DNQX into the dorsomedial striatum increased the frequency and duration of social play, whereas infusion of B&M tended to have the same effect. Inactivation of the nucleus accumbens (NAcc) core using B&M increased duration but not frequency of social play, whereas B&M infusion into the NAcc shell did not influence social play behavior. Thus, functional integrity of the medial PFC is important for the expression of social play behavior. Glutamatergic inputs into the dorsomedial striatum exert an inhibitory influence on social play, and functional activity in the NAcc core acts to limit the length of playful interactions. These results highlight the importance of prefrontal and striatal circuits implicated in cognitive control, decision making, behavioral inhibition, and reward-associated processes in social play behavior." @default.
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- W2015184348 date "2013-04-08" @default.
- W2015184348 modified "2023-10-06" @default.
- W2015184348 title "Social Play Behavior in Adolescent Rats is Mediated by Functional Activity in Medial Prefrontal Cortex and Striatum" @default.
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- W2015184348 cites W1982604070 @default.
- W2015184348 cites W1983541428 @default.
- W2015184348 cites W1985645068 @default.
- W2015184348 cites W1990070054 @default.
- W2015184348 cites W1991271750 @default.
- W2015184348 cites W1996885559 @default.
- W2015184348 cites W1997732184 @default.
- W2015184348 cites W2000655626 @default.
- W2015184348 cites W2004448205 @default.
- W2015184348 cites W2009539632 @default.
- W2015184348 cites W2016899938 @default.
- W2015184348 cites W2021486758 @default.
- W2015184348 cites W2021635027 @default.
- W2015184348 cites W2023891230 @default.
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- W2015184348 cites W2032471499 @default.
- W2015184348 cites W2034369724 @default.
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- W2015184348 cites W2047033542 @default.
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- W2015184348 cites W2062981179 @default.
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- W2015184348 cites W2076156575 @default.
- W2015184348 cites W2077523950 @default.
- W2015184348 cites W2078189006 @default.
- W2015184348 cites W2081194315 @default.
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- W2015184348 cites W2089325249 @default.
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- W2015184348 doi "https://doi.org/10.1038/npp.2013.83" @default.
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