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- W2015187866 abstract "Abstract In this study we examined the effect of diesel exhaust (DE) exposure on the disposition of a typical polycyclic aromatic hydrocarbon. DE-exposed and nonexposed A/Jax mice were divided into three groups and each mouse instilled intratracheally with benzo[ a ]pyrene (B a P). One group ( A ) received 14 C-B a P, and at intervals of 2, 24, and 168 h, three mice from the group were killed and quick frozen for whole body autoradiography. Sagittal sections were cut at 0.5 mm intervals and autoradiograms prepared. Adjacent sections were studied so that radioactive areas were matched to specific organs. The second group ( B ) received 3 H-B a P and at 2, 24, and 168 h these mice were killed. Livers, lungs, and testes were weighed and frozen. From these tissues metabolites were analyzed; these data are reported in the next paper. Histofluorescent examination of tissues from mice instilled with nonradioactive B a P (group C ) confirmed that B a P was present in the lung. The autoradiography data are the basis for elucidating the B a P distribution in the mouse. Within 2 h after instillation radioactivity was detected in the entire animal, with most in lungs, liver, and GI tract. By 24 h after instillation considerable radioactivity had redistributed to the GI tract. At 168 h after instillation only a trace of label was found in the GI mucosa." @default.
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- W2015187866 date "1981-01-01" @default.
- W2015187866 modified "2023-09-27" @default.
- W2015187866 title "Benzo[a]pyrene metabolism in mice exposed to diesel exhaust: I. Uptake and distribution" @default.
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- W2015187866 doi "https://doi.org/10.1016/0160-4120(81)90075-1" @default.
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