FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015191569> ?p ?o ?g. }

• W2015191569 endingPage "238" @default.
• W2015191569 startingPage "227" @default.
• W2015191569 abstract "Although much evidence has been accumulated suggesting that tumor necrosis factor-α (TNF-α) is an important mediator of insulin resistance, the precise mechanism involved is still unclear. Recently, it has been reported that insulin-induced glucose uptake is mediated by activation of second messengers such as insulin receptor substrate 1 (IRS-1), phosphatidylinositol 3-kinase (PI3K), and diacylglycerol (DG)-protein kinase C (PKC). We have examined the effect of TNF-α on insulin-induced glucose uptake and activations of tyrosine kinase, IRS-1, PI3K and PKC in rat adipocytes. Pretreatment with 0.1–100 nM TNF-α for 60 min resulted in a significant decrease in 10 nM insulin- or 1 μM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake. 10 nM insulin-stimulated activation of tyrosine kinase, IRS-1 and PI3K was suppressed by preincubation with 0.1–10 nM TNF-α for 60 min. 10 nM TNF-α pretreatment also suppressed 10 nM insulin- and 1 μM TPA-induced increases in membrane-associated PKCβ and PKCζ. Furthermore, 10 nM TNF-α, by itself, altered PKCβ translocation from the membrane to cytosol. These results suggest that TNF-α inhibits insulin-stimulated activation of both the tyrosine kinase-IRS-1-PI3K-PKCζ pathway and DG-PKC pathway. Finally, TNF-α contributes to insulin resistance in rat adipocytes." @default.
• W2015191569 created "2016-06-24" @default.
• W2015191569 creator A5034898325 @default.
• W2015191569 creator A5036738100 @default.
• W2015191569 creator A5043944239 @default.
• W2015191569 creator A5049484965 @default.
• W2015191569 creator A5051342257 @default.
• W2015191569 creator A5064578968 @default.
• W2015191569 creator A5066404637 @default.
• W2015191569 creator A5071923481 @default.
• W2015191569 date "1999-04-01" @default.
• W2015191569 modified "2023-10-17" @default.
• W2015191569 title "Effect of tumor necrosis factor-α on insulin signal transduction in rat adipocytes: relation to PKCβ and ζ translocation" @default.
• W2015191569 cites W1487365829 @default.
• W2015191569 cites W1503737214 @default.
• W2015191569 cites W1508913819 @default.
• W2015191569 cites W1521975179 @default.
• W2015191569 cites W1533740425 @default.
• W2015191569 cites W1563745823 @default.
• W2015191569 cites W1597210981 @default.
• W2015191569 cites W1641731911 @default.
• W2015191569 cites W1915505624 @default.
• W2015191569 cites W1964069732 @default.
• W2015191569 cites W1965602524 @default.
• W2015191569 cites W1967850153 @default.
• W2015191569 cites W1968805130 @default.
• W2015191569 cites W1970347484 @default.
• W2015191569 cites W1971762417 @default.
• W2015191569 cites W1974033843 @default.
• W2015191569 cites W1975299036 @default.
• W2015191569 cites W1976352707 @default.
• W2015191569 cites W1977572155 @default.
• W2015191569 cites W1977795081 @default.
• W2015191569 cites W1984969980 @default.
• W2015191569 cites W1988870963 @default.
• W2015191569 cites W1991010434 @default.
• W2015191569 cites W1993282564 @default.
• W2015191569 cites W1994035739 @default.
• W2015191569 cites W1998562562 @default.
• W2015191569 cites W2017136915 @default.
• W2015191569 cites W2017729786 @default.
• W2015191569 cites W2019379544 @default.
• W2015191569 cites W2021230116 @default.
• W2015191569 cites W2022801078 @default.
• W2015191569 cites W2022930571 @default.
• W2015191569 cites W2030986279 @default.
• W2015191569 cites W2031504435 @default.
• W2015191569 cites W2037972567 @default.
• W2015191569 cites W2039372097 @default.
• W2015191569 cites W2041797033 @default.
• W2015191569 cites W2051760834 @default.
• W2015191569 cites W2053200285 @default.
• W2015191569 cites W2091536410 @default.
• W2015191569 cites W2126544407 @default.
• W2015191569 cites W2129316761 @default.
• W2015191569 cites W2130678313 @default.
• W2015191569 cites W2143873575 @default.
• W2015191569 cites W21727487 @default.
• W2015191569 cites W2225039358 @default.
• W2015191569 doi "https://doi.org/10.1016/s0167-4889(99)00016-6" @default.
• W2015191569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10209302" @default.
• W2015191569 hasPublicationYear "1999" @default.
• W2015191569 type Work @default.
• W2015191569 sameAs 2015191569 @default.
• W2015191569 citedByCount "22" @default.
• W2015191569 countsByYear W20151915692014 @default.
• W2015191569 countsByYear W20151915692015 @default.
• W2015191569 countsByYear W20151915692017 @default.
• W2015191569 countsByYear W20151915692020 @default.
• W2015191569 crossrefType "journal-article" @default.
• W2015191569 hasAuthorship W2015191569A5034898325 @default.
• W2015191569 hasAuthorship W2015191569A5036738100 @default.
• W2015191569 hasAuthorship W2015191569A5043944239 @default.
• W2015191569 hasAuthorship W2015191569A5049484965 @default.
• W2015191569 hasAuthorship W2015191569A5051342257 @default.
• W2015191569 hasAuthorship W2015191569A5064578968 @default.
• W2015191569 hasAuthorship W2015191569A5066404637 @default.
• W2015191569 hasAuthorship W2015191569A5071923481 @default.
• W2015191569 hasConcept C112446052 @default.
• W2015191569 hasConcept C126322002 @default.
• W2015191569 hasConcept C134018914 @default.
• W2015191569 hasConcept C185967709 @default.
• W2015191569 hasConcept C195794163 @default.
• W2015191569 hasConcept C2777391703 @default.
• W2015191569 hasConcept C2777866211 @default.
• W2015191569 hasConcept C2779306644 @default.
• W2015191569 hasConcept C2780610907 @default.
• W2015191569 hasConcept C36020004 @default.
• W2015191569 hasConcept C42362537 @default.
• W2015191569 hasConcept C62478195 @default.
• W2015191569 hasConcept C71924100 @default.
• W2015191569 hasConcept C86803240 @default.
• W2015191569 hasConcept C95444343 @default.
• W2015191569 hasConceptScore W2015191569C112446052 @default.
• W2015191569 hasConceptScore W2015191569C126322002 @default.
• W2015191569 hasConceptScore W2015191569C134018914 @default.
• W2015191569 hasConceptScore W2015191569C185967709 @default.
• W2015191569 hasConceptScore W2015191569C195794163 @default.

• next