FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015193409> ?p ?o ?g. }

• W2015193409 endingPage "3988" @default.
• W2015193409 startingPage "3977" @default.
• W2015193409 abstract "Neural crest cells that form the vertebrate head skeleton migrate and interact with surrounding tissues to shape the skull, and defects in these processes underlie many human craniofacial syndromes. Signals at the midline play a crucial role in the development of the anterior neurocranium, which forms the ventral braincase and palate, and here we explore the role of Hedgehog (Hh) signaling in this process. Using sox10:egfp transgenics to follow neural crest cell movements in the living embryo, and vital dye labeling to generate a fate map, we show that distinct populations of neural crest form the two main cartilage elements of the larval anterior neurocranium: the paired trabeculae and the midline ethmoid. By analyzing zebrafish mutants that disrupt sonic hedgehog (shh)expression, we demonstrate that shh is required to specify the movements of progenitors of these elements at the midline, and to induce them to form cartilage. Treatments with cyclopamine, to block Hh signaling at different stages, suggest that although requirements in morphogenesis occur during neural crest migration beneath the brain, requirements in chondrogenesis occur later, as cells form separate trabecular and ethmoid condensations. Cell transplantations indicate that these also reflect different sources of Shh, one from the ventral neural tube that controls trabecular morphogenesis and one from the oral ectoderm that promotes chondrogenesis. Our results suggest a novel role for Shh in the movements of neural crest cells at the midline, as well as in their differentiation into cartilage, and help to explain why both skeletal fusions and palatal clefting are associated with the loss of Hh signaling in holoprosencephalic humans." @default.
• W2015193409 created "2016-06-24" @default.
• W2015193409 creator A5026401238 @default.
• W2015193409 creator A5032617904 @default.
• W2015193409 creator A5032991265 @default.
• W2015193409 creator A5044327929 @default.
• W2015193409 creator A5044471260 @default.
• W2015193409 creator A5085698112 @default.
• W2015193409 date "2005-09-01" @default.
• W2015193409 modified "2023-10-17" @default.
• W2015193409 title "Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull" @default.
• W2015193409 cites W1566859644 @default.
• W2015193409 cites W1570966949 @default.
• W2015193409 cites W1964958795 @default.
• W2015193409 cites W1966435498 @default.
• W2015193409 cites W1972029559 @default.
• W2015193409 cites W1972700427 @default.
• W2015193409 cites W1973880156 @default.
• W2015193409 cites W1974723367 @default.
• W2015193409 cites W1975513365 @default.
• W2015193409 cites W1983448619 @default.
• W2015193409 cites W1989586315 @default.
• W2015193409 cites W1998756807 @default.
• W2015193409 cites W1999139999 @default.
• W2015193409 cites W1999754144 @default.
• W2015193409 cites W2002249795 @default.
• W2015193409 cites W2005511744 @default.
• W2015193409 cites W2007663039 @default.
• W2015193409 cites W2017204222 @default.
• W2015193409 cites W2024002091 @default.
• W2015193409 cites W2030180991 @default.
• W2015193409 cites W2031455229 @default.
• W2015193409 cites W2034715594 @default.
• W2015193409 cites W2036303174 @default.
• W2015193409 cites W2037084194 @default.
• W2015193409 cites W2037499635 @default.
• W2015193409 cites W2042932723 @default.
• W2015193409 cites W2059614045 @default.
• W2015193409 cites W2060823106 @default.
• W2015193409 cites W2072595310 @default.
• W2015193409 cites W2076278553 @default.
• W2015193409 cites W2079679324 @default.
• W2015193409 cites W2097803027 @default.
• W2015193409 cites W2098304591 @default.
• W2015193409 cites W2100455164 @default.
• W2015193409 cites W2104784626 @default.
• W2015193409 cites W2108707301 @default.
• W2015193409 cites W2123715306 @default.
• W2015193409 cites W2125349610 @default.
• W2015193409 cites W2128801071 @default.
• W2015193409 cites W2141055051 @default.
• W2015193409 cites W2156952955 @default.
• W2015193409 cites W2160372979 @default.
• W2015193409 cites W2167561785 @default.
• W2015193409 cites W2170616123 @default.
• W2015193409 cites W4239966793 @default.
• W2015193409 doi "https://doi.org/10.1242/dev.01943" @default.
• W2015193409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16049113" @default.
• W2015193409 hasPublicationYear "2005" @default.
• W2015193409 type Work @default.
• W2015193409 sameAs 2015193409 @default.
• W2015193409 citedByCount "262" @default.
• W2015193409 countsByYear W20151934092012 @default.
• W2015193409 countsByYear W20151934092013 @default.
• W2015193409 countsByYear W20151934092014 @default.
• W2015193409 countsByYear W20151934092015 @default.
• W2015193409 countsByYear W20151934092016 @default.
• W2015193409 countsByYear W20151934092017 @default.
• W2015193409 countsByYear W20151934092018 @default.
• W2015193409 countsByYear W20151934092019 @default.
• W2015193409 countsByYear W20151934092020 @default.
• W2015193409 countsByYear W20151934092021 @default.
• W2015193409 countsByYear W20151934092022 @default.
• W2015193409 countsByYear W20151934092023 @default.
• W2015193409 crossrefType "journal-article" @default.
• W2015193409 hasAuthorship W2015193409A5026401238 @default.
• W2015193409 hasAuthorship W2015193409A5032617904 @default.
• W2015193409 hasAuthorship W2015193409A5032991265 @default.
• W2015193409 hasAuthorship W2015193409A5044327929 @default.
• W2015193409 hasAuthorship W2015193409A5044471260 @default.
• W2015193409 hasAuthorship W2015193409A5085698112 @default.
• W2015193409 hasConcept C103607123 @default.
• W2015193409 hasConcept C104317684 @default.
• W2015193409 hasConcept C105702510 @default.
• W2015193409 hasConcept C126749454 @default.
• W2015193409 hasConcept C196843134 @default.
• W2015193409 hasConcept C197849852 @default.
• W2015193409 hasConcept C2776637008 @default.
• W2015193409 hasConcept C2776878037 @default.
• W2015193409 hasConcept C2777605378 @default.
• W2015193409 hasConcept C2778539099 @default.
• W2015193409 hasConcept C2779300802 @default.
• W2015193409 hasConcept C2779713988 @default.
• W2015193409 hasConcept C2780071072 @default.
• W2015193409 hasConcept C2780550940 @default.
• W2015193409 hasConcept C2780594696 @default.
• W2015193409 hasConcept C35496256 @default.
• W2015193409 hasConcept C40692019 @default.

• next