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- W2015196105 abstract "Letters and Corrections1 February 1985Trimethoprim-Sulfamethoxazole and Folinic AcidCHRISTOPHER STOCK, B.A.CHRISTOPHER STOCK, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-2-277_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In a recent letter Kinzie and Taylor (1) discuss their rationale for recommending the prophylactic use of folinic acid for patients receiving high doses of trimethoprim-sulfamethoxazole. Although there are legitimate concerns about hematologic toxicity from high doses of trimethoprim-sulfamethoxazole, I have reservations about the routine use of folinic acid. To date there are no well-designed studies with trimethoprim-sulfamethoxazole or other antifolates that compare treatment outcomes when using or omitting folinic acid.The inference thatPneumocystis carinii, the frequent target of high-dose trimethoprim-sulfamethoxazole, cannot utilize exogenous folinic acid is probably correct as it is generally thought that protozoa...References1. KINZIETAYLOR BJ. Trimethoprim and folinic acid [Letter]. Ann Intern Med. 1984;101:565. LinkGoogle Scholar2. FERONEHITCHINGS RG. Folate cofactor biosynthesis by Plasmodium berghei: comparison of folate and dihydrofolate as substrates. J Protozool. 1966;13:504-6. CrossrefMedlineGoogle Scholar3. GILES C. The treatment of Toxoplasma uveitis with pyrimethamine and folinic acid. Am J Ophthalmol. 1964;58:611-7. CrossrefMedlineGoogle Scholar4. KAHNFEINBRODSKY SSI. Effects of trimethoprim on folate metabolism in man. Clin Pharmacol Ther. 1968;9:550-9. CrossrefMedlineGoogle Scholar5. JAFFEAMMANNABRAMSLEWISGOLDEN SADBJ. Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet. 1983;2:1109-11. CrossrefMedlineGoogle Scholar6. KOVACSHIEMENZMACHER JJA. Pneumocystis carinii pneumonia: a comparison between patients with acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar1. KINZIETAYLOR BJ. Trimethoprim and folinic acid [Letter]. Ann Intern Med. 1984;101:565. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University of Utah Salt Lake City, UT 81123 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIron Deficiency and Megaloblastic Anemias 1 February 1985Volume 102, Issue 2Page: 277-277KeywordsPneumocystisToxicity Issue Published: 1 February 1985 PDF downloadLoading ..." @default.
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- W2015196105 title "Trimethoprim-Sulfamethoxazole and Folinic Acid" @default.
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