Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015199940> ?p ?o ?g. }
- W2015199940 endingPage "530" @default.
- W2015199940 startingPage "524" @default.
- W2015199940 abstract "Free radical scavenging and antioxidant activities of 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (compound A) and diphenyl diselenide (PhSe)2 were examined and compared for inhibition of Fe(II) and sodium nitroprusside (SNP) stimulated lipid peroxidation in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable free radical and their glutathione peroxidase (GPx) like antioxidant activities with H2O2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize mono- and di-thiols were also evaluated. This study revealed that an amino group in amino diselenide drastically enhances their catalytic activities in the aromatic thiol (PhSH) assay system. Compound A was ∼2-fold more active than (PhSe)2 in both tBuOOH and H2O2 assay systems. In addition, the present results showed that (PhSe)2 exhibited an increased ability to oxidize di-thiols, compound A was not a good substrate for the oxidation of thiol used namely DTT, cystine and DMPS. The antioxidant potency against Fe(II) and SNP-induced brain TBARS were in this order [(compound A); IC50 2 μM and 4 μM] > [(PhSe)2; IC50 19 μM and 27.5 μM. Compound A showed DPPH radical-scavenging activity. This study provides in vitro evidence anti-oxidant action of the tested organoselenium compounds, that the nitrogen atom in the organochalcogens can have a profound effect on their antioxidant activity." @default.
- W2015199940 created "2016-06-24" @default.
- W2015199940 creator A5014804546 @default.
- W2015199940 creator A5015116496 @default.
- W2015199940 creator A5032578352 @default.
- W2015199940 creator A5044324691 @default.
- W2015199940 creator A5046905615 @default.
- W2015199940 creator A5088021168 @default.
- W2015199940 creator A5091794375 @default.
- W2015199940 date "2014-06-01" @default.
- W2015199940 modified "2023-09-23" @default.
- W2015199940 title "1-(2-(2-(2-(1-Aminoethyl)phenyl)diselanyl)phenyl)ethanamine: An amino organoselenium compound with interesting antioxidant profile" @default.
- W2015199940 cites W1858816790 @default.
- W2015199940 cites W1964102757 @default.
- W2015199940 cites W1965476204 @default.
- W2015199940 cites W1972989329 @default.
- W2015199940 cites W1976445447 @default.
- W2015199940 cites W1983310681 @default.
- W2015199940 cites W1986669241 @default.
- W2015199940 cites W1987478997 @default.
- W2015199940 cites W1987973555 @default.
- W2015199940 cites W1990484506 @default.
- W2015199940 cites W1992326531 @default.
- W2015199940 cites W1993722218 @default.
- W2015199940 cites W2006370393 @default.
- W2015199940 cites W2008302182 @default.
- W2015199940 cites W2015938989 @default.
- W2015199940 cites W2024356127 @default.
- W2015199940 cites W2034046060 @default.
- W2015199940 cites W2042700527 @default.
- W2015199940 cites W2044286734 @default.
- W2015199940 cites W2048553024 @default.
- W2015199940 cites W2055609777 @default.
- W2015199940 cites W2061643619 @default.
- W2015199940 cites W2067114364 @default.
- W2015199940 cites W2068120671 @default.
- W2015199940 cites W2071195046 @default.
- W2015199940 cites W2091049190 @default.
- W2015199940 cites W2114775998 @default.
- W2015199940 cites W2141670884 @default.
- W2015199940 cites W2167763549 @default.
- W2015199940 cites W2408805972 @default.
- W2015199940 cites W2949422841 @default.
- W2015199940 cites W306944446 @default.
- W2015199940 cites W61637986 @default.
- W2015199940 doi "https://doi.org/10.1016/j.tiv.2013.12.010" @default.
- W2015199940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24394197" @default.
- W2015199940 hasPublicationYear "2014" @default.
- W2015199940 type Work @default.
- W2015199940 sameAs 2015199940 @default.
- W2015199940 citedByCount "16" @default.
- W2015199940 countsByYear W20151999402015 @default.
- W2015199940 countsByYear W20151999402016 @default.
- W2015199940 countsByYear W20151999402017 @default.
- W2015199940 countsByYear W20151999402018 @default.
- W2015199940 countsByYear W20151999402019 @default.
- W2015199940 countsByYear W20151999402020 @default.
- W2015199940 countsByYear W20151999402021 @default.
- W2015199940 countsByYear W20151999402023 @default.
- W2015199940 crossrefType "journal-article" @default.
- W2015199940 hasAuthorship W2015199940A5014804546 @default.
- W2015199940 hasAuthorship W2015199940A5015116496 @default.
- W2015199940 hasAuthorship W2015199940A5032578352 @default.
- W2015199940 hasAuthorship W2015199940A5044324691 @default.
- W2015199940 hasAuthorship W2015199940A5046905615 @default.
- W2015199940 hasAuthorship W2015199940A5088021168 @default.
- W2015199940 hasAuthorship W2015199940A5091794375 @default.
- W2015199940 hasConcept C155647269 @default.
- W2015199940 hasConcept C178790620 @default.
- W2015199940 hasConcept C185592680 @default.
- W2015199940 hasConcept C2778004101 @default.
- W2015199940 hasConcept C2778760513 @default.
- W2015199940 hasConcept C2778979269 @default.
- W2015199940 hasConcept C2779138974 @default.
- W2015199940 hasConcept C2779754636 @default.
- W2015199940 hasConcept C2781324293 @default.
- W2015199940 hasConcept C2781401929 @default.
- W2015199940 hasConcept C553756173 @default.
- W2015199940 hasConcept C71240020 @default.
- W2015199940 hasConceptScore W2015199940C155647269 @default.
- W2015199940 hasConceptScore W2015199940C178790620 @default.
- W2015199940 hasConceptScore W2015199940C185592680 @default.
- W2015199940 hasConceptScore W2015199940C2778004101 @default.
- W2015199940 hasConceptScore W2015199940C2778760513 @default.
- W2015199940 hasConceptScore W2015199940C2778979269 @default.
- W2015199940 hasConceptScore W2015199940C2779138974 @default.
- W2015199940 hasConceptScore W2015199940C2779754636 @default.
- W2015199940 hasConceptScore W2015199940C2781324293 @default.
- W2015199940 hasConceptScore W2015199940C2781401929 @default.
- W2015199940 hasConceptScore W2015199940C553756173 @default.
- W2015199940 hasConceptScore W2015199940C71240020 @default.
- W2015199940 hasIssue "4" @default.
- W2015199940 hasLocation W20151999401 @default.
- W2015199940 hasLocation W20151999402 @default.
- W2015199940 hasOpenAccess W2015199940 @default.
- W2015199940 hasPrimaryLocation W20151999401 @default.
- W2015199940 hasRelatedWork W1836097862 @default.
- W2015199940 hasRelatedWork W1994416168 @default.