Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015200483> ?p ?o ?g. }
- W2015200483 endingPage "831" @default.
- W2015200483 startingPage "823" @default.
- W2015200483 abstract "Maternal diabetes-induced neural tube defects (NTDs) are associated with increased programmed cell death (apoptosis) in the neuroepithelium, which is related to intracellular nitrosative stress. To alleviate nitrosative stress, diabetic pregnant mice were fed via gavage an inhibitor of nitric oxide (NO) synthase (NOS) 2, L-N6-(1-iminoethyl)-lysine (L-NIL; 80 mg/kg), once a day from embryonic (E) day 7.5 to 9.5 during early stages of neurulation. The treatment significantly reduced NTD rate in the embryos, compared with that in vehicle (normal saline)-treated diabetic group. In addition to alleviation of nitrosative stress, endoplasmic reticulum (ER) stress was also ameliorated, assessed by quantification of associated factors. Apoptosis was reduced, indicated by caspase 8 activation. These results show that nitrosative stress is important in diabetes-induced NTDs via exacerbating ER stress, leading to increased apoptosis. Oral treatment with NOS-2 inhibitor alleviates nitrosative and ER stress, decreases apoptosis, and reduces NTDs in the embryos, providing information for further interventional studies to reduce diabetes-associated birth defects." @default.
- W2015200483 created "2016-06-24" @default.
- W2015200483 creator A5000749676 @default.
- W2015200483 creator A5088444651 @default.
- W2015200483 creator A5090679738 @default.
- W2015200483 date "2012-08-01" @default.
- W2015200483 modified "2023-10-18" @default.
- W2015200483 title "Reduction in Embryonic Malformations and Alleviation of Endoplasmic Reticulum Stress by Nitric Oxide Synthase Inhibition in Diabetic Embryopathy" @default.
- W2015200483 cites W1570192366 @default.
- W2015200483 cites W1905806846 @default.
- W2015200483 cites W1967245379 @default.
- W2015200483 cites W1968918028 @default.
- W2015200483 cites W1975112964 @default.
- W2015200483 cites W1976046875 @default.
- W2015200483 cites W1976161806 @default.
- W2015200483 cites W1976285457 @default.
- W2015200483 cites W1979404773 @default.
- W2015200483 cites W1985479666 @default.
- W2015200483 cites W1987077891 @default.
- W2015200483 cites W1988740497 @default.
- W2015200483 cites W1991484350 @default.
- W2015200483 cites W1991923928 @default.
- W2015200483 cites W1993755642 @default.
- W2015200483 cites W1997018082 @default.
- W2015200483 cites W1999605572 @default.
- W2015200483 cites W2005857572 @default.
- W2015200483 cites W2006659891 @default.
- W2015200483 cites W2013624095 @default.
- W2015200483 cites W2018623775 @default.
- W2015200483 cites W2021992999 @default.
- W2015200483 cites W2023175037 @default.
- W2015200483 cites W2023701209 @default.
- W2015200483 cites W2024650410 @default.
- W2015200483 cites W2032049429 @default.
- W2015200483 cites W2032231831 @default.
- W2015200483 cites W2036473942 @default.
- W2015200483 cites W2040925087 @default.
- W2015200483 cites W2046110868 @default.
- W2015200483 cites W2046671201 @default.
- W2015200483 cites W2049100069 @default.
- W2015200483 cites W2057792332 @default.
- W2015200483 cites W2065061627 @default.
- W2015200483 cites W2074187719 @default.
- W2015200483 cites W2075249754 @default.
- W2015200483 cites W2078370448 @default.
- W2015200483 cites W2079759543 @default.
- W2015200483 cites W2079973428 @default.
- W2015200483 cites W2081731224 @default.
- W2015200483 cites W2082916190 @default.
- W2015200483 cites W2084889841 @default.
- W2015200483 cites W2088917778 @default.
- W2015200483 cites W2097046090 @default.
- W2015200483 cites W2100480970 @default.
- W2015200483 cites W2100603371 @default.
- W2015200483 cites W2100902882 @default.
- W2015200483 cites W2107682100 @default.
- W2015200483 cites W2110787746 @default.
- W2015200483 cites W2116427780 @default.
- W2015200483 cites W2131587288 @default.
- W2015200483 cites W2132851955 @default.
- W2015200483 cites W2136028363 @default.
- W2015200483 cites W2137719941 @default.
- W2015200483 cites W2138266804 @default.
- W2015200483 cites W2161154819 @default.
- W2015200483 cites W2171807788 @default.
- W2015200483 cites W2226892380 @default.
- W2015200483 doi "https://doi.org/10.1177/1933719111434543" @default.
- W2015200483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4046311" @default.
- W2015200483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22534324" @default.
- W2015200483 hasPublicationYear "2012" @default.
- W2015200483 type Work @default.
- W2015200483 sameAs 2015200483 @default.
- W2015200483 citedByCount "22" @default.
- W2015200483 countsByYear W20152004832013 @default.
- W2015200483 countsByYear W20152004832014 @default.
- W2015200483 countsByYear W20152004832015 @default.
- W2015200483 countsByYear W20152004832016 @default.
- W2015200483 countsByYear W20152004832017 @default.
- W2015200483 countsByYear W20152004832018 @default.
- W2015200483 countsByYear W20152004832019 @default.
- W2015200483 countsByYear W20152004832021 @default.
- W2015200483 countsByYear W20152004832023 @default.
- W2015200483 crossrefType "journal-article" @default.
- W2015200483 hasAuthorship W2015200483A5000749676 @default.
- W2015200483 hasAuthorship W2015200483A5088444651 @default.
- W2015200483 hasAuthorship W2015200483A5090679738 @default.
- W2015200483 hasBestOaLocation W20152004832 @default.
- W2015200483 hasConcept C102225024 @default.
- W2015200483 hasConcept C126322002 @default.
- W2015200483 hasConcept C129536746 @default.
- W2015200483 hasConcept C134018914 @default.
- W2015200483 hasConcept C139447449 @default.
- W2015200483 hasConcept C158617107 @default.
- W2015200483 hasConcept C16685009 @default.
- W2015200483 hasConcept C185592680 @default.
- W2015200483 hasConcept C190283241 @default.
- W2015200483 hasConcept C196843134 @default.
- W2015200483 hasConcept C2777622882 @default.