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• W201520138 abstract "Publisher Summary This chapter discusses sensory receptors and mechanotransduction. The chapter is limited to cells (usually neurons) that transmit sensory information into one or more divisions of the central nervous system. The chapter discusses several concepts, including sensory transduction, mechanoreceptors, and efferent control of mechanoreceptors. Mechanoreception can be viewed as a three-stage process that comprises coupling, transduction, and encoding. Vertebrate receptors, arthropod receptors, and muscle mechanoreceptors are discussed under mechanoreceptors. Characterization of mechanically activated channels is proceeding, but it is important to realize that no single-channel recordings have yet been unequivocally linked to mechanotransduction in any mechanosensory neuron. The encoding of action potentials from receptor current and the general control of receptor excitability involves voltage and calcium-activated ion channels that are very similar to those in other tissues, and complete models of encoding in some receptors are now available. Adaptation and general dynamic properties of mechanoreception occur in both the coupling and encoding stages of the process. Efferent control of transduction and adaptation in mechanoreceptors is probably common, but generally not well understood. Mechanoreception is a widespread and crucial process for many physiological functions. Recent developments in electrophysiological techniques and new experimental preparations have provided important information about each stage of mechanoreception from initial deformation to action potential production, but much remains to be learned. When the molecules responsible for mechanotransduction are known, it should be possible to discover how they are linked to other cellular components to confer mechanical sensitivity, and from there to move on to complete models of mechanoreception in intact cells." @default.
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• W201520138 date "2001-01-01" @default.
• W201520138 modified "2023-09-25" @default.
• W201520138 title "Sensory Receptors and Mechanotransduction" @default.
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• W201520138 doi "https://doi.org/10.1016/b978-012656976-6/50137-2" @default.
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