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- W2015207561 abstract "Abstract In vitro models may represent a useful approach for studying the biotransformation of xenobiotics in animals. However, the value of such models can only be established by relating in vitro results with in vivo data. In fish, several investigators have compared xenobiotic metabolism in vivo with xenobiotic metabolism in subcellular liver fractions. In contrast, the biotransformation of chemicals in isolated fish hepatocytes has been scarcely studied. The objective of this work carried out in rainbow trout was to compare the metabolism of a widespread branched alkane (pristane) in isolated hepatocytes with metabolism in vivo and in liver microsomal fractions. The incubation of hepatocytes with [3H] pristane led to pristanol, pristane-diol and pristanic acid, while pristanol appeared to be the only product in microsomal preparations. In the in vivo experiment, liver contained significant amounts of pristanol and pristanic acid whereas conjugates of pristanol and pristane-diol were found in bile. Thus, the metabolism of pristane in hepatocytes suspension correlates with in vivo biotransformation better than does metabolism in microsomes." @default.
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- W2015207561 date "1989-01-01" @default.
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- W2015207561 title "Hydroxylation of pristane by isolated hepatocytes of rainbow trout: a comparison with in vivo metabolism and biotransformation by liver microsomes" @default.
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- W2015207561 doi "https://doi.org/10.1016/0141-1136(89)90176-1" @default.
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