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- W2015213501 abstract "The importance of adenyl cyclase and adenosine 3',5'-monophosphate in the induction of tyrosine aminotransferase by adrenocorticosteroids has been tested in HTC cells derived from a rat hepatoma and grown in tissue culture. Adrenocorticosteroids cause a 10-to 15-fold increase in the rate of synthesis of tyrosine aminotransferase in these cells. Under various experimental conditions, with or without glucocorticoids, neither adenyl cyclase nor cyclic adenosine mono-phosphate could be detected in HTC cells. In addition, neither the cyclic nucleotide nor N(6), O(2')-dibutyryl cyclic adenosine monophosphate caused increased activity of the transaminase in HTC cells. We conclude that induction of tyrosine aminotransferase by glucocorticoids is not mediated by the adenyl cyclase-cyclic adenosine monophosphate system." @default.
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- W2015213501 date "1968-11-29" @default.
- W2015213501 modified "2023-09-26" @default.
- W2015213501 title "Tyrosine Aminotransferase: Enzyme Induction Independent of Adenosine 3′,5′-Monophosphate" @default.
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- W2015213501 doi "https://doi.org/10.1126/science.162.3857.1018" @default.
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