FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015214599> ?p ?o ?g. }

• W2015214599 endingPage "534" @default.
• W2015214599 startingPage "525" @default.
• W2015214599 abstract "Nonsyndromic orofacial clefts (OFC) are common birth defects caused by certain genes interacting with environmental factors. Mutations and association studies indicate that the homeobox gene MSX1 plays a role in human clefting. In a Dutch case-control triad study (mother, father, and child), we investigated interactions between MSX1 and the parents’ periconceptional lifestyle in relation to the risk of OFC in their offspring. We studied 181 case- and 132 control mothers, 155 case- and 121 control fathers, and 176 case- and 146 control children, in which there were 107 case triads and 66 control triads. Univariable and multivariable logistic regression analyses were applied, and odds ratios (OR), 95% confidence intervals (CI) were calculated. Allele 4 of the CA marker in the MSX1 gene, consisting of nine CA repeats, was the most common allele found in both the case and control triads. Significant interactions were observed between allele 4 homozygosity of the child with maternal smoking (OR 2.7, 95% CI 1.1–6.6) and with smoking by both parents (OR 4.9, 95% CI 1.4–18.0). Allele 4 homozygosity in the mother and smoking showed a risk estimate of OR 3.2 (95% CI 1.1–9.0). If allele 4 homozygous mothers did not take daily folic acid supplements in the recommended periconceptional period, this also increased the risk of OFC for their offspring (OR 2.8, 95% CI 1.1–6.7). Our findings show that, in the Dutch population, periconceptional smoking by both parents interacts with a specific allelic variant of MSX1 to significantly increase OFC risk for their offspring. Possible underlying mechanisms are discussed." @default.
• W2015214599 created "2016-06-24" @default.
• W2015214599 creator A5005626266 @default.
• W2015214599 creator A5023585572 @default.
• W2015214599 creator A5034848455 @default.
• W2015214599 creator A5055953390 @default.
• W2015214599 creator A5060181673 @default.
• W2015214599 creator A5065281862 @default.
• W2015214599 creator A5084505810 @default.
• W2015214599 creator A5091832997 @default.
• W2015214599 date "2008-10-19" @default.
• W2015214599 modified "2023-10-18" @default.
• W2015214599 title "The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts" @default.
• W2015214599 cites W1963641861 @default.
• W2015214599 cites W1965222408 @default.
• W2015214599 cites W1968702701 @default.
• W2015214599 cites W1976463940 @default.
• W2015214599 cites W1984924519 @default.
• W2015214599 cites W1994358122 @default.
• W2015214599 cites W1999239960 @default.
• W2015214599 cites W2007104998 @default.
• W2015214599 cites W2008916306 @default.
• W2015214599 cites W2021402727 @default.
• W2015214599 cites W2028288805 @default.
• W2015214599 cites W2028512350 @default.
• W2015214599 cites W2029220352 @default.
• W2015214599 cites W2035136671 @default.
• W2015214599 cites W2040404307 @default.
• W2015214599 cites W2043801822 @default.
• W2015214599 cites W2048005096 @default.
• W2015214599 cites W2055573396 @default.
• W2015214599 cites W2062821778 @default.
• W2015214599 cites W2081680395 @default.
• W2015214599 cites W2082059743 @default.
• W2015214599 cites W2095255382 @default.
• W2015214599 cites W2102147956 @default.
• W2015214599 cites W2107493520 @default.
• W2015214599 cites W2112098758 @default.
• W2015214599 cites W2114235784 @default.
• W2015214599 cites W2114239498 @default.
• W2015214599 cites W2116403328 @default.
• W2015214599 cites W2119005131 @default.
• W2015214599 cites W2119149080 @default.
• W2015214599 cites W2120331418 @default.
• W2015214599 cites W2129806528 @default.
• W2015214599 cites W2130773424 @default.
• W2015214599 cites W2131036795 @default.
• W2015214599 cites W2134666960 @default.
• W2015214599 cites W2137231843 @default.
• W2015214599 cites W2139231790 @default.
• W2015214599 cites W2141541691 @default.
• W2015214599 cites W2145108229 @default.
• W2015214599 cites W2147183806 @default.
• W2015214599 cites W2151432694 @default.
• W2015214599 cites W2151992416 @default.
• W2015214599 cites W2152490686 @default.
• W2015214599 cites W2156925439 @default.
• W2015214599 cites W2165724850 @default.
• W2015214599 cites W2172122920 @default.
• W2015214599 cites W4252950463 @default.
• W2015214599 doi "https://doi.org/10.1007/s00439-008-0569-6" @default.
• W2015214599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18932005" @default.
• W2015214599 hasPublicationYear "2008" @default.
• W2015214599 type Work @default.
• W2015214599 sameAs 2015214599 @default.
• W2015214599 citedByCount "34" @default.
• W2015214599 countsByYear W20152145992012 @default.
• W2015214599 countsByYear W20152145992013 @default.
• W2015214599 countsByYear W20152145992014 @default.
• W2015214599 countsByYear W20152145992015 @default.
• W2015214599 countsByYear W20152145992017 @default.
• W2015214599 countsByYear W20152145992020 @default.
• W2015214599 countsByYear W20152145992022 @default.
• W2015214599 crossrefType "journal-article" @default.
• W2015214599 hasAuthorship W2015214599A5005626266 @default.
• W2015214599 hasAuthorship W2015214599A5023585572 @default.
• W2015214599 hasAuthorship W2015214599A5034848455 @default.
• W2015214599 hasAuthorship W2015214599A5055953390 @default.
• W2015214599 hasAuthorship W2015214599A5060181673 @default.
• W2015214599 hasAuthorship W2015214599A5065281862 @default.
• W2015214599 hasAuthorship W2015214599A5084505810 @default.
• W2015214599 hasAuthorship W2015214599A5091832997 @default.
• W2015214599 hasBestOaLocation W20152145991 @default.
• W2015214599 hasConcept C104317684 @default.
• W2015214599 hasConcept C112672928 @default.
• W2015214599 hasConcept C126322002 @default.
• W2015214599 hasConcept C146304588 @default.
• W2015214599 hasConcept C156957248 @default.
• W2015214599 hasConcept C180754005 @default.
• W2015214599 hasConcept C197754878 @default.
• W2015214599 hasConcept C2779234561 @default.
• W2015214599 hasConcept C44249647 @default.
• W2015214599 hasConcept C54355233 @default.
• W2015214599 hasConcept C71924100 @default.
• W2015214599 hasConcept C86803240 @default.
• W2015214599 hasConceptScore W2015214599C104317684 @default.
• W2015214599 hasConceptScore W2015214599C112672928 @default.
• W2015214599 hasConceptScore W2015214599C126322002 @default.

• next