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• W2015215105 abstract "Pitavastatin: evidence for its place in treatment of hypercholesterolemia Peter Alagona, JrPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USAAbstract: Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are the most potent pharmacologic agents for lowering total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). They have become an accepted standard of care in the treatment of patients with known atherosclerotic cardiovascular disease (secondary prevention) and also those at increased risk of cardiovascular events. There are currently six statin drugs commercially available in the US. Although they are chemically similar and have the same primary mechanisms of action in lowering TC and LDL-C, there are differences in their efficacy or potency, metabolism, drug–drug interactions, and individual tolerability. Considering the numbers of patients who need LDL-C-lowering therapy and questions of individual tolerance and therapeutic response, having a variety of agents to choose from is beneficial for patient care. This paper presents background information on statin treatment and reviews data regarding a new agent, pitavastatin, which has recently been approved for clinical use.Keywords: HMG CoA reductase inhibitors, statins, pitavastatin, class effect, low-density lipoprotein" @default.
• W2015215105 created "2016-06-24" @default.
• W2015215105 creator A5080115476 @default.
• W2015215105 date "2010-10-01" @default.
• W2015215105 modified "2023-09-27" @default.
• W2015215105 title "Pitavastatin: evidence for its place in treatment of hypercholesterolemia" @default.
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• W2015215105 doi "https://doi.org/10.2147/ce.s8008" @default.
• W2015215105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3065553" @default.
• W2015215105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21468365" @default.
• W2015215105 hasPublicationYear "2010" @default.
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