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- W2015216410 endingPage "462" @default.
- W2015216410 startingPage "447" @default.
- W2015216410 abstract "Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis, hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard treatment, a combination of pegylated interferon alfa and ribavirin, eradicates the virus in only about 50% of patients. Directly acting antiviral (DAA) agents, which inhibit HCV replication, are in phase 1, 2, and 3 trials; these include reagents that target the nonstructural (NS)3 protease, the NS5A protein, the RNA-dependent RNA-polymerase NS5B, as well as compounds that directly inhibit HCV replication through interaction with host cell proteins. Because of the high genetic heterogeneity of HCV and its rapid replication, monotherapy with DAA agents poses a high risk for selection of resistant variants. We review the parameters that determine resistance, genotypic and phenotypic resistance profiles of DAA agents, and strategies to avoid the selection of resistant variants." @default.
- W2015216410 created "2016-06-24" @default.
- W2015216410 creator A5045504446 @default.
- W2015216410 creator A5070817587 @default.
- W2015216410 date "2010-02-01" @default.
- W2015216410 modified "2023-10-17" @default.
- W2015216410 title "Resistance to Direct Antiviral Agents in Patients With Hepatitis C Virus Infection" @default.
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