Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015217355> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2015217355 endingPage "2000" @default.
- W2015217355 startingPage "1996" @default.
- W2015217355 abstract "Licochalcone A, a flavonoid found in licorice root (Glycyrrhiza glabra), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μM licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G1 to S phase. In addition, 5 μM licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest." @default.
- W2015217355 created "2016-06-24" @default.
- W2015217355 creator A5001628077 @default.
- W2015217355 creator A5009421517 @default.
- W2015217355 creator A5016933435 @default.
- W2015217355 creator A5044736819 @default.
- W2015217355 creator A5075083918 @default.
- W2015217355 creator A5089708349 @default.
- W2015217355 creator A5090619031 @default.
- W2015217355 date "2008-01-01" @default.
- W2015217355 modified "2023-10-03" @default.
- W2015217355 title "Anti-proliferative Effect of Licochalcone A on Vascular Smooth Muscle Cells" @default.
- W2015217355 cites W1960658940 @default.
- W2015217355 cites W1968840212 @default.
- W2015217355 cites W1977756111 @default.
- W2015217355 cites W1985214827 @default.
- W2015217355 cites W2013097901 @default.
- W2015217355 cites W2015981852 @default.
- W2015217355 cites W2017298776 @default.
- W2015217355 cites W2031799324 @default.
- W2015217355 cites W2042660701 @default.
- W2015217355 cites W2043385366 @default.
- W2015217355 cites W2045317411 @default.
- W2015217355 cites W2063650204 @default.
- W2015217355 cites W2071602099 @default.
- W2015217355 cites W2084260624 @default.
- W2015217355 cites W2087593774 @default.
- W2015217355 cites W2107354908 @default.
- W2015217355 cites W2125678486 @default.
- W2015217355 cites W2127150495 @default.
- W2015217355 cites W2155058150 @default.
- W2015217355 doi "https://doi.org/10.1248/bpb.31.1996" @default.
- W2015217355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18981562" @default.
- W2015217355 hasPublicationYear "2008" @default.
- W2015217355 type Work @default.
- W2015217355 sameAs 2015217355 @default.
- W2015217355 citedByCount "20" @default.
- W2015217355 countsByYear W20152173552012 @default.
- W2015217355 countsByYear W20152173552013 @default.
- W2015217355 countsByYear W20152173552014 @default.
- W2015217355 countsByYear W20152173552015 @default.
- W2015217355 countsByYear W20152173552018 @default.
- W2015217355 countsByYear W20152173552019 @default.
- W2015217355 countsByYear W20152173552021 @default.
- W2015217355 countsByYear W20152173552023 @default.
- W2015217355 crossrefType "journal-article" @default.
- W2015217355 hasAuthorship W2015217355A5001628077 @default.
- W2015217355 hasAuthorship W2015217355A5009421517 @default.
- W2015217355 hasAuthorship W2015217355A5016933435 @default.
- W2015217355 hasAuthorship W2015217355A5044736819 @default.
- W2015217355 hasAuthorship W2015217355A5075083918 @default.
- W2015217355 hasAuthorship W2015217355A5089708349 @default.
- W2015217355 hasAuthorship W2015217355A5090619031 @default.
- W2015217355 hasBestOaLocation W20152173551 @default.
- W2015217355 hasConcept C1491633281 @default.
- W2015217355 hasConcept C170493617 @default.
- W2015217355 hasConcept C180361614 @default.
- W2015217355 hasConcept C185592680 @default.
- W2015217355 hasConcept C199835354 @default.
- W2015217355 hasConcept C2775960820 @default.
- W2015217355 hasConcept C29537977 @default.
- W2015217355 hasConcept C55493867 @default.
- W2015217355 hasConcept C62112901 @default.
- W2015217355 hasConcept C86803240 @default.
- W2015217355 hasConcept C95444343 @default.
- W2015217355 hasConceptScore W2015217355C1491633281 @default.
- W2015217355 hasConceptScore W2015217355C170493617 @default.
- W2015217355 hasConceptScore W2015217355C180361614 @default.
- W2015217355 hasConceptScore W2015217355C185592680 @default.
- W2015217355 hasConceptScore W2015217355C199835354 @default.
- W2015217355 hasConceptScore W2015217355C2775960820 @default.
- W2015217355 hasConceptScore W2015217355C29537977 @default.
- W2015217355 hasConceptScore W2015217355C55493867 @default.
- W2015217355 hasConceptScore W2015217355C62112901 @default.
- W2015217355 hasConceptScore W2015217355C86803240 @default.
- W2015217355 hasConceptScore W2015217355C95444343 @default.
- W2015217355 hasIssue "11" @default.
- W2015217355 hasLocation W20152173551 @default.
- W2015217355 hasLocation W20152173552 @default.
- W2015217355 hasOpenAccess W2015217355 @default.
- W2015217355 hasPrimaryLocation W20152173551 @default.
- W2015217355 hasRelatedWork W2383820488 @default.
- W2015217355 hasRelatedWork W2391067398 @default.
- W2015217355 hasRelatedWork W2532041 @default.
- W2015217355 hasRelatedWork W2750728167 @default.
- W2015217355 hasRelatedWork W3010117194 @default.
- W2015217355 hasRelatedWork W3010867174 @default.
- W2015217355 hasRelatedWork W3209090203 @default.
- W2015217355 hasRelatedWork W4244660752 @default.
- W2015217355 hasRelatedWork W4280493527 @default.
- W2015217355 hasRelatedWork W4380538005 @default.
- W2015217355 hasVolume "31" @default.
- W2015217355 isParatext "false" @default.
- W2015217355 isRetracted "false" @default.
- W2015217355 magId "2015217355" @default.
- W2015217355 workType "article" @default.