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- W2015217687 abstract "Until very recently, treatment for chronic hepatitis C virus (HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011 (Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first time since the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples." @default.
- W2015217687 created "2016-06-24" @default.
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- W2015217687 date "2013-01-01" @default.
- W2015217687 modified "2023-10-04" @default.
- W2015217687 title "Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective" @default.
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- W2015217687 cites W1815984339 @default.
- W2015217687 cites W1943743452 @default.
- W2015217687 cites W1963726813 @default.
- W2015217687 cites W1967930625 @default.
- W2015217687 cites W1969637183 @default.
- W2015217687 cites W1971800756 @default.
- W2015217687 cites W1974960822 @default.
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- W2015217687 cites W2006034254 @default.
- W2015217687 cites W2010127051 @default.
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- W2015217687 doi "https://doi.org/10.5501/wjv.v2.i1.6" @default.
- W2015217687 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3785043" @default.
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