Matches in SemOpenAlex for { <https://semopenalex.org/work/W2015218053> ?p ?o ?g. }
- W2015218053 endingPage "211" @default.
- W2015218053 startingPage "198" @default.
- W2015218053 abstract "Migration of glial cells is an essential step in the development of the antennal lobe, the primary olfactory center of insects, to establish well-defined borders between olfactory glomeruli required for odor discrimination. In the present study, we used two-photon microscopy to visualize calcium signaling in developing antennal lobe glial cells of the sphinx moth Manduca sexta. We found a correlation between the upregulation of functional voltage-gated calcium channels and the onset of glial cell migration. In addition, glial cells migrating into the center of the antennal lobe express larger voltage-gated calcium transients than glial cells that remain at the periphery. Migration behavior and calcium signaling of glial cells in vivo were manipulated either by deafferentation, by injection of the calcium channel blockers diltiazem, verapamil, and flunarizine, or by injection of the calcium chelators BAPTA-AM and Fluo-4-AM. In deafferented antennal lobes, glial cells failed to express functional voltage-gated calcium channels and did not migrate. Calcium channel blockage or reducing glial calcium signals by calcium chelators prevented glial cell migration and resulted in antennal lobes lacking glial borders around glomeruli, indicating that voltage-gated calcium signaling is required for the migration of antennal lobe glial cells and the development of mature olfactory glomeruli." @default.
- W2015218053 created "2016-06-24" @default.
- W2015218053 creator A5020292456 @default.
- W2015218053 creator A5024648073 @default.
- W2015218053 creator A5089529779 @default.
- W2015218053 date "2005-01-01" @default.
- W2015218053 modified "2023-09-24" @default.
- W2015218053 title "Blockage of voltage-gated calcium signaling impairs migration of glial cells in vivo" @default.
- W2015218053 cites W1479941048 @default.
- W2015218053 cites W1493311870 @default.
- W2015218053 cites W1516209325 @default.
- W2015218053 cites W1544941962 @default.
- W2015218053 cites W155567317 @default.
- W2015218053 cites W1608352250 @default.
- W2015218053 cites W1926921372 @default.
- W2015218053 cites W1965943283 @default.
- W2015218053 cites W1966212277 @default.
- W2015218053 cites W1966759762 @default.
- W2015218053 cites W1975596049 @default.
- W2015218053 cites W1978936152 @default.
- W2015218053 cites W1979365412 @default.
- W2015218053 cites W1987794083 @default.
- W2015218053 cites W1991754496 @default.
- W2015218053 cites W1993579552 @default.
- W2015218053 cites W1995138630 @default.
- W2015218053 cites W1996833245 @default.
- W2015218053 cites W2000137518 @default.
- W2015218053 cites W2001851378 @default.
- W2015218053 cites W2002921297 @default.
- W2015218053 cites W2003037534 @default.
- W2015218053 cites W2006374456 @default.
- W2015218053 cites W2006602134 @default.
- W2015218053 cites W2009691568 @default.
- W2015218053 cites W2009793382 @default.
- W2015218053 cites W2023331462 @default.
- W2015218053 cites W2027215260 @default.
- W2015218053 cites W2033594595 @default.
- W2015218053 cites W2033987226 @default.
- W2015218053 cites W2038073702 @default.
- W2015218053 cites W2039375647 @default.
- W2015218053 cites W2044285262 @default.
- W2015218053 cites W2045460359 @default.
- W2015218053 cites W2052478430 @default.
- W2015218053 cites W2054012828 @default.
- W2015218053 cites W2057258868 @default.
- W2015218053 cites W2077477013 @default.
- W2015218053 cites W2081172496 @default.
- W2015218053 cites W2085533054 @default.
- W2015218053 cites W2085949167 @default.
- W2015218053 cites W2088792983 @default.
- W2015218053 cites W2089089225 @default.
- W2015218053 cites W2089598622 @default.
- W2015218053 cites W2092364585 @default.
- W2015218053 cites W2102546734 @default.
- W2015218053 cites W2104845360 @default.
- W2015218053 cites W2117260074 @default.
- W2015218053 cites W2121175498 @default.
- W2015218053 cites W2131470040 @default.
- W2015218053 cites W2144997267 @default.
- W2015218053 cites W2151582772 @default.
- W2015218053 cites W2161123040 @default.
- W2015218053 cites W2161987929 @default.
- W2015218053 cites W2164814468 @default.
- W2015218053 cites W2167567717 @default.
- W2015218053 cites W2169518110 @default.
- W2015218053 cites W1965537228 @default.
- W2015218053 doi "https://doi.org/10.1002/glia.20163" @default.
- W2015218053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15712206" @default.
- W2015218053 hasPublicationYear "2005" @default.
- W2015218053 type Work @default.
- W2015218053 sameAs 2015218053 @default.
- W2015218053 citedByCount "40" @default.
- W2015218053 countsByYear W20152180532012 @default.
- W2015218053 countsByYear W20152180532013 @default.
- W2015218053 countsByYear W20152180532014 @default.
- W2015218053 countsByYear W20152180532015 @default.
- W2015218053 countsByYear W20152180532019 @default.
- W2015218053 countsByYear W20152180532021 @default.
- W2015218053 countsByYear W20152180532022 @default.
- W2015218053 countsByYear W20152180532023 @default.
- W2015218053 crossrefType "journal-article" @default.
- W2015218053 hasAuthorship W2015218053A5020292456 @default.
- W2015218053 hasAuthorship W2015218053A5024648073 @default.
- W2015218053 hasAuthorship W2015218053A5089529779 @default.
- W2015218053 hasConcept C105702510 @default.
- W2015218053 hasConcept C126322002 @default.
- W2015218053 hasConcept C169760540 @default.
- W2015218053 hasConcept C18699975 @default.
- W2015218053 hasConcept C201571599 @default.
- W2015218053 hasConcept C201792869 @default.
- W2015218053 hasConcept C2776032975 @default.
- W2015218053 hasConcept C2780019300 @default.
- W2015218053 hasConcept C2780050217 @default.
- W2015218053 hasConcept C2780884517 @default.
- W2015218053 hasConcept C28406088 @default.
- W2015218053 hasConcept C30979828 @default.
- W2015218053 hasConcept C519063684 @default.
- W2015218053 hasConcept C529278444 @default.